...NF1 mutations are described as the major melanoma drivers, but approximately 20% of patients lack these mutations and ar...
...NF1]), providing an additional link between these tumors and the mitogen-activated protein kinase (MAPK) signaling pathw...
...NF1) (79%), and neurogenic locus notch homolog protein 1 (NOTCH1) (79%). In multivariable analysis, mutation of epiderma...
...NF1 mutation (p<0.05). Before PSM, the mOS for patients with multiple gliomas was shorter than that for those with solit...
...NF1) plexiform neurofibromas (pNFs) are associated with a variety of symptoms and concerns that affect patients' quality...
...Nf1flox/mut GFAP-Cre (FMC) mice and age-matched Nf1flox/flox (FF) controls were euthanized at defined intervals from 2 w...
...NF1), NF-κB signaling (PRKCB, CSNK1A1), PI-3-kinase signaling (PIK3R1, VAV1), RHOA/cytoskeleton remodeling (ARHGEF3), RN...
...NF1 loss) have a negligible correlation with single-drug or combination efficacy, reinforcing the importance of postgene...
...NF1 alteration and 21q loss in glioblastoma, and EGFR amplification and 22q loss in IDH1/2-mutant astrocytoma. Leveragin...
...NF1 4.5 % (n = 1). Additionally, 2 carriers of monoallelic germline variants in MUTYH were identified. No significant di...
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