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Wu(Y),Li(W),Wu(M) Front Oncol None

...BRCA1/2 and PALB2 mutations-has revealed a targetable vulnerability through the DNA damage response (DDR) pathway. This ...

Watlington(WK),Dayanidhi(DL),Zokaasadi(M),... Mol Oncol 2026-06-30

...BRCA1 long transcripts, rendering cells susceptible to combination therapy with PARP inhibitors. To further assess the c...

Bedell(M),Kim(S),Mohebnasab(M),Bell(D) Head Neck Pathol 2026-06-30

...BRCA1 mutation, confirmed to be germline on subsequent germline testing. The patient was treated with surgical resection...

Namey(E),Horton(C),Dudley(B),Carraway(C),K... JAMA Netw Open 2026-06-01

...BRCA1, BRCA2, CHEK2, or PALB2) genes. Statistical analyses were conducted between June 2023 and March 2025. Identificati...

Huang(J),Liu(X),Floyd(W),Haugh(W),Sun(Z),K... JCI Insight 2026-08-24

...BRCA1-associated protein 1 (BAP1) as a potent tumor suppressor in STS. Integrative analyses using RNA sequencing, multip...

Allister(BA),Hofmann(W),Lühmann(JL),Sander... NPJ Breast Cancer 2026-06-30

...BRCA1, BRCA2, and other diagnostically consented core genes. We hypothesized that variants in further DNA repair genes, ...

Giansanti(C),Schultz(JC),Jackson(J),Vindig... Nat Commun 2026-06-30

...BRCA1 deficiency. These findings reveal that FET protein assemblies modulate replication stress responses, influencing g...

Lin(X),Hua(Z),Liu(C),Yang(M),Zhang(B),Zhu(... Exploration (Beijing) 2026-06-00

...BRCA1 to restrain BRCA1 ubiquitination and degradation, thereby enhancing homologous recombination repair signaling. Int...

Qutob(N),Hindiyeh(M),Zahdeh(F),Alian(A),Th... Front Genet None

...BRCA1/2 panel. Whole-exome sequencing (WES) was subsequently performed in BRCA-negative probands to identify additional ...

Kotb(A),Hassan(WA) Ecancermedicalscience None

...BRCA1, BRCA2 and other high-penetrance gene mutations, can identify women at elevated risk, enabling proactive surveilla...