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A vicious cycle inducer in gastric pathogenesis: implication of Helicobacter ...

Rajaei(A),Mahdavi(P),Chimehrad(R),Zakeri(M... Arch Microbiol 2026-01-12

...BRCA1/2 pathway deficiency) state, which is a homologous recombination DNA repair deficiency, promoting error-prone repa...

Whole genome sequencing approach to assess homologous recombination deficienc...

Al Assaad(M),Hadi(K),Levine(MF),Guevara(D)... Commun Med (Lond) 2026-01-12

...BRCA1/2 mutations; 24% of HRD cases are BRCA1/2 wild-type. A diverse range of gene alterations involved in HRD are eluci...

Genetic tumor syndromes in female cancer: insights into inherited cancer pred...

Krückel(A),Gocke(J),Hörner(M),Keller(K),Mü... Arch Gynecol Obstet 2026-01-13

...BRCA1/2 variants to include numerous pathogenic variants of other high- and moderate-risk genes. A broad spectrum of gen...

Supplementary biomarker testing in molecular tumor boards increases actionabl...

Scheiter(A),Mellin(S),Keil(F),Meier(J),Heu... BMC Med 2026-01-14

...BRCA1/2, including PALB2, ATM, and CHEK2. ADC IHC supported 20 recommendations and two therapy implementations. The inte...

The emerging role of progesterone receptor modulators in breast physiology, c...

Liberty(A),Edelman(A),Bernhardt(SM) BMJ Sex Reprod Health 2026-01-15

...BRCA1 carriers. Outside of genetic cancer risk, PRMs decrease background parenchymal enhancement on breast magnetic reso...

Circadian disruption increases sperm DNA damage through impaired CREB1-mediat...

Zhu(W),Hu(M),Zhang(Y),Lian(Y),Xu(Z),Huang(... Biol Reprod 2026-01-11

...BRCA1, MRE11, and RAD51. Luciferase reporter and ChIP assay confirmed the transcriptional regulation of CREB1 on BRCA1 e...

CRISPR/Cas9-mediated TOP1 knockout in chicken DF-1 cells reveals its critical...

Lv(X),Wei(Q),Zhi(Q),Liu(X),Li(F),Niu(Y),Su... J Anim Sci 2026-01-08

...BRCA1). These results demonstrate that TOP1 is essential for maintaining genomic stability in avian somatic cells, and i...

Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in ...

Alhourani(F),Tauziet(M),Ayeul(M),Dambrun(P... Cancer Res 2026-01-02

...BRCA1-mediated homologous recombination processes, ultimately leading to extensive cancer cell death and significant inh...

Comparison of MR Imaging of High-grade Serous Carcinomas with and without Hom...

Saida(T),Shikama(A),Yoshida(M),Amano(T),Is... Magn Reson Med Sci 2026-01-27

...BRCA1 variant, 9 patients with BRCA2 variant, and 22 without BRCA variants) and 18 patients with HRD-negative HGSC were ...

Cancer Incidence Rates Between BRCA1/2 Pathogenic Variant Carriers and Non-Ca...

Ebata(A),Tada(H),Harada-Shoji(N),Hamanaka(... Tohoku J Exp Med 2026-06-02

...BRCA1/2 pathogenic variant (PV) carriers. BRCA1/2 PV carriers in Japan are reported to be also more susceptible to esoph...

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