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Spiekman(IAC),Mehra(N),Zeverijn(LJ),Geurts... Int J Cancer 2026-03-15

BRCA1/2 are crucial in the homologous recombination repair (HRR) pathway, with loss-of-function (LoF) alterations predic...

Zuo(Y),Zhang(K),Zhang(M),Wang(T),Zhu(Y),Wa... Eur J Med Chem 2026-01-15

...BRCA1 and BRCA2. Exploring the relationship between Polθ and cancer may offer new therapeutic strategies. This review ou...

Moyer(CL),Hill(JL),Coleman(D),Lanier(A),Ma... Cancer Prev Res (Phila) 2026-03-03

...Brca1-deficient with modest toxicities. In some of the MMTV-ErbB2 mice, IRX4204 completely prevented mammary tumor forma...

Browne(IM),Pascual(J),Cutts(RJ),Kingston(B... Clin Cancer Res 2026-01-06

...BRCA1/BRCA2/PALB2 wild type. Baseline low ctDNA levels predict response to targeted therapy, potentially suggesting shar...

Wang(L),Wang(Y),Guo(S),Jiang(B),Guo(C),Wan... Eur J Med Chem 2026-01-15

...BRCA1 mutant breast cancer HCC-1937 cell line (IC50 = 0.88 ± 0.21 μM). The mechanism study demonstrated that compound 13...

Li(C),Zhao(X),Li(X),Wang(C),Huo(Z),Xu(X),K... Cancer Res 2026-02-02

...BRCA1 and subsequent recruitment of BRCA1 to DNA damage sites. The phosphorylation-dependent interaction enhanced HR rep...

Evans(DG),Morgan(RD),Forde(C),Crosbie(EJ),... J Med Genet 2026-01-20

...BRCA1/2 with testing for CNVs. Overall, 6744 BC and 3291 OC cases were tested. For BC, 453 (6.7%) PVs were detected in B...

Lynce(F),Graham(N),Kochupurakkal(BS),Nguye... Clin Cancer Res 2026-02-04

...BRCA1/2-mutated HER2-negative metastatic breast cancer. In this phase Ib investigator-sponsored study of sapacitabine an...

Yamada(A),Oshi(M),Isa(T),Koyasu(T),Takatsu... Jpn J Clin Oncol 2026-03-13

...BRCA1 PGV individuals (55.0%). RRSO was conducted in 30 of 41 individuals (73.1%), with higher rates among BRCA1 and BRC...

Ikegami(M),Zhang(L),Hirata(M),Yamaguchi(T)... Clin Cancer Res 2026-02-17

...BRCA1 and/or BRCA2 (13%-16% in ovarian/peritoneal cancers), and NF1 (16% in peripheral nerve tumors). Genes with >50% GC...