...BRCA1 or a BRCA2 mutation, individual carrier status predicts the risk of breast cancer. In relatives of cases where bot...
Ancestral mutations in BRCA1 and BRCA2 are common in people of Ashkenazi Jewish descent and are associated with a substa...
...Brca1 results in a homologous-repair deficiency. Repair is mildly reduced in Brca1 wild-type cells and severely reduced ...
...BRCA1, 9% for DAPK1, and 0% for KL. Furthermore, hypermethylation of 5 to 7 loci of these genes was significantly correl...
...BRCA1/2 carriers and non-carriers. Age at surgery and years since surgery did not affect risk reductions.,Both BRCA1/2 m...
...BRCA1 and BRCA2 genes. The results showed that 10 of 19 individuals had mutations or variants of BRCA1 or BRCA2, and 6 o...
...BRCA1 and BRCA2 genes have been of great interest, these genes account for less than 5% of all breast carcinoma cases. T...
...BRCA1 mutations and 12 BRCA2 mutations. BRCA heterozygotes were younger compared with Jewish patients who had EOC withou...
To assess the retinal function in BRCA1 gene mutation carriers and to evaluate the clinical significance of its potentia...
...BRCA1 to enhance AR- and GRIP1-mediated transactivation. As such, BRCA2 can exert its tumor suppressor function, in part...
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