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Differential involvement of the hMRE11/hRAD50/NBS1 complex, BRCA1 and MLH1 in...

Habraken(Yvette),Jolois(Olivier),Piette(Ja... Oncogene 2003-10-07

...BRCA1 or MLH1 were analysed. NBS- and hMRE11-deficient cells present a classical kinetic of NF-kappaB induction after ca...

Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutati...

Modugno(Francesmary),Moslehi(Roxana),Ness(... Cancer Causes Control 2003-12-04

...BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 c...

Distinct genetic and epigenetic changes in medullary breast cancer.

Osin(P),Lu(Y-J),Stone(J),Crook(T),Houlston... Int J Surg Pathol 2003-11-28

...BRCA1-associated tumors. A high level of BRCA1 promoter hypermethylation was detected, suggesting a possible role of thi...

Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, i...

Sutherland(Kate D),Visvader(Jane E),Choong... Int J Cancer 2003-10-09

...BRCA1 and that LMO4 can repress its transcriptional activity. Since proto-oncogene deregulation can result from activati...

A novel ubiquitin ligase is deficient in Fanconi anemia.

Meetei(Amom Ruhikanta),de Winter(Johan P),... Nat Genet 2003-12-08

...BRCA1 and BRCA2 (refs. 1,2). A key step in this pathway is monoubiquitination of FANCD2, resulting in the redistribution...

Glomeruloid microvascular proliferation is associated with p53 expression, ge...

Goffin(J R),Straume(O),Chappuis(P O),Brune... Br J Cancer 2003-10-17

...BRCA1 germline mutations. The presence of GMP may influence treatment decisions.

[Inherited predisposition to breast cancer: after the BRCA1 and BRCA2 genes, ...

Bonadona(Valérie),Lasset(Christine) Bull Cancer 2003-09-22

Germline mutations of the breast cancer predisposing known genes, BRCA1 and BRCA2, with an autosomal dominant transmissi...

BRCA1 in cancer, cell cycle and genomic stability.

Jhanwar-Uniyal(Meena) Front Biosci 2003-10-24

...BRCA1 is not accompanied by underlying mutation of the gene in tumor cells with loss of heterozygosity for the BRCA1 gen...

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconve...

Wu-Baer(Foon),Lagrazon(Karen),Yuan(Wei),Ba... J Biol Chem 2003-11-12

...BRCA1/BARD1 are not known, BRCA1 autoubiquitination occurs principally by conjugation with K6-linked polymers. The abili...

Emerging roles of BRCA1 alternative splicing.

Orban(T I),Olah(E) Mol Pathol 2003-11-06

Germline mutations of the BRCA1 gene predispose individuals mainly to the development of breast and/or ovarian cancer. H...

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