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Uptake of risk-reducing medical interventions among female BRCA1/2 pathogenic...

Lloyd-Ellis(S),Kaur(P),Kwon(JS),Dawson(L),... Gynecol Oncol 2026-07-00

Being a female with a germline BRCA1 or BRCA2 pathogenic variant (PV) elevates risks of developing breast and ovarian ca...

Mesothelioma in situ-spectrum pleural lesions: Diagnostic challenges and long...

Pezzuto(F),Giraudo(C),Biondini(D),Pontorie... Pathol Res Pract 2026-09-00

...BRCA1-associated protein 1 (BAP1) or methylthioadenosine phosphorylase (MTAP) loss of expression, and absence of stromal...

Single-cell multiomics gene regulatory landscape reveals impaired spermatogon...

Lin(N),Zhang(Z),Sha(X),Yao(J),Sun(X),Sun(R... J Genet Genomics 2026-05-20

...BRCA1 and E2F1. This work provides resources for understanding testicular senescence and nominates ZFX and CXCL13 as pot...

Functional analysis of a splicing variant of the DOCK8 gene in a patient with...

Gervas(P),Salakhov(R),Molokov(A),Karpova(Y... Asian Pac J Cancer Prev 2026-05-01

BRCA1/2 founder mutation have been detected in various populations and ethnicities. Molecular diagnosis of HBOC remains ...

Identification and exploration of potential N6-methylation related mRNAs in e...

He(Y),Ren(C),Lei(L),Li(J),Zhang(G) Front Genet None

...BRCA1, CCNA2 and CDK1 might be vital m6A-related mRNAs, and VCAM1 and RAP1A may be the most important two. A few crucial...

HOXB13, a high-risk prostate cancer gene, also confers risk for breast cancer...

Ozen(F),Yegin(Z),Sayit(D) J Hum Genet 2026-09-00

...BRCA1 and BRCA2, are primarily responsible for inherited breast cancers, while mutations in moderate-risk genes also inc...

USP7 inhibition perturbs proteostasis and tumorigenesis in triple-negative br...

Kim(A),Gopalakrishnan(P),Suárez-Pizarro(M)... NPJ Breast Cancer 2026-05-23

...BRCA1-A DNA damage repair complex, suggesting a USP7-TOPORS-BRCA1-A axis that might further explain the continued prolif...

Semantic embedding of variant effect annotations enables rapid and accurate p...

Wu(J),Stutzman(M),Muriello(M),Lincoln(J),B... Sci Rep 2026-05-23

...BRCA1, BRCA2, FBN1, ATM, PALB2, MYH7, USH2A, and PAH), achieving Leave-One-Out Cross-Validation (LOO-CV) MCC of 0.895-0....

Translational prioritization of strategies to overcome poly ADP-ribose polyme...

Shen(K),Cai(L) Discov Oncol 2026-05-24

...BRCA1-mutant models. In contrast, strategies aimed at restoring homologous recombination exhibited strong in vitro syner...

Breast cancer chemotherapy in transition: predictive markers, resistance mech...

Sharma(R),Toppo(L),Satapathy(P),Arcot(R),M... Front Oncol None

...BRCA1/2 status, homologous recombination deficiency (HRD), tumor-infiltrating lymphocytes (TILs), Ki-67, intrinsic molec...

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