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Germ-line variants in methyl-group metabolism genes and susceptibility to DNA...

Paz(Maria F),Avila(Sonia),Fraga(Mario F),P... Cancer Res 2002-09-11

...BRCA1, RAR beta 2, CDH1, and RASSF1). Two positive associations were found. First, carriers of genotypes containing the ...

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic i...

Weaver(Zoë),Montagna(Cristina),Xu(Xiaoling... Oncogene 2002-08-16

BRCA1 mutation carriers have an increased susceptibility to breast and ovarian cancer. Excision of exon 11 of Brca1 in t...

Germ line BRCA1 & BRCA2 mutations in Greek breast/ovarian cancer families: 53...

Ladopoulou(A),Kroupis(C),Konstantopoulou(I... Cancer Lett 2002-11-07

...BRCA1 and three in BRCA2. The known founder mutation 5382insC of BRCA1 was identified in seven unrelated families. The o...

Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor.

McGowan(Clare H) Bioessays 2002-08-12

...Brca1. A role for Cds1 in repair is suggested by the finding that it interacts with the Holliday junction resolving acti...

Sex hormone-binding globulin polymorphisms in familial and sporadic breast ca...

Försti(Asta),Jin(Qianren),Grzybowska(Ewa),... Carcinogenesis 2002-09-05

...BRCA1/BRCA2 mutation, Nordic familial and sporadic breast cancer cases. The reported G to A polymorphism in exon 1 was n...

Targeted substrate degradation by an engineered double RING ubiquitin ligase.

Oyake(Daisuke),Nishikawa(Hiroyuki),Koizuka... Biochem Biophys Res Commun 2002-08-29

...BRCA1 and BARD1 linked to a substrate recognition site PCNA, which is known to interact with cyclin-dependent kinase inh...

BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage.

Nieuwenhuis(B),Van Assen-Bolt(A J),Van Waa... Int J Radiat Biol 2002-06-14

...BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although th...

Increased ionizing radiation sensitivity and genomic instability in the absen...

Bassing(Craig H),Chua(Katrin F),Sekiguchi(... Proc Natl Acad Sci U S A 2002-08-02

...BRCA1 focus formation. Our findings indicate that H2AX function is essential for mammalian DNA repair and genomic stabil...

Analysis of BRCA1 and BRCA2 in breast and breast/ovarian cancer families show...

Vega(A),Torres(M),Martínez(J I),Ruiz-Ponte... Ann Hum Genet 2002-10-01

...BRCA1 gene: 330 A>G, 910_913delGTTC, 2121 C>T, 3958_3962delCTCAGinsAGGC, and 5530 T>A. The BRCA1 330 A>G mutation was fo...

Effect of germ-line genetic variation on breast cancer survival in a populati...

Goode(Ellen L),Dunning(Alison M),Kuschel(B... Cancer Res 2002-07-16

...BRCA1/2 mutations and genotyped for polymorphisms in 22 DNA repair, hormone metabolism, carcinogen metabolism, and other...

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