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TP53 BRCA1 CRISPR single-cell cancer

Schouten(Jan P),McElgunn(Cathal J),Waaijer... Nucleic Acids Res 2002-06-28

...BRCA1, MSH2 and MLH1 genes, detection of trisomies such as Down's syndrome, characterisation of chromosomal aberrations ...

Claes(Kathleen),Vandesompele(Jo),Poppe(Bru... Oncogene 2002-07-03

...BRCA1-Deltaex5 (isoform with an in frame skip of exon 5) ratio to the total BRCA1 expression level. IVS5+3A>G results in...

Welcsh(Piri L),Lee(Ming K),Gonzalez-Hernan... Proc Natl Acad Sci U S A 2002-07-01

...BRCA1 caused by inherited mutation and tissue-specific somatic mutation leads to breast and ovarian cancer. Nearly all B...

Bassing(Craig H),Chua(Katrin F),Sekiguchi(... Proc Natl Acad Sci U S A 2002-08-02

...BRCA1 focus formation. Our findings indicate that H2AX function is essential for mammalian DNA repair and genomic stabil...

Berry(Donald A),Iversen(Edwin S),Gudbjarts... J Clin Oncol 2002-06-20

...BRCA1 and BRCA2. Genetic testing for BRCA1 and BRCA2 is highly sensitive, missing an estimated 15% of mutations. In the ...

Zhong(Qing),Chen(Chi-Fen),Chen(Phang-Lang)... J Biol Chem 2002-09-09

...Brca1(+/+):p53(-/-) or Brca1(-/-):p53(-/-). The Brca1(-/-):p53(-/-) MEFs appear to be extremely sensitive to ionizing ra...

Goode(Ellen L),Dunning(Alison M),Kuschel(B... Cancer Res 2002-07-16

...BRCA1/2 mutations and genotyped for polymorphisms in 22 DNA repair, hormone metabolism, carcinogen metabolism, and other...

Rose(S L),Buller(R E) Minerva Ginecol 2002-10-28

...BRCA1 gene in 1994 has proven to be of great interest to the study of hereditary ovarian cancer. BRCA1 gene mutation con...

Sibanda(B L),Critchlow(S E),Begun(J),Pei(X... Nat Struct Biol 2002-01-02

...BRCA1 C-terminal (BRCT) domains. In the complex, a single ligase chain binds asymmetrically to an Xrcc4 dimer. The helic...

Venkitaraman(A R) J Cell Sci 2002-03-05

Inheritance of one defective copy of either of the two breast-cancer-susceptibility genes, BRCA1 and BRCA2, predisposes ...

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