Brca1 C-terminal (BRCT) domains are a common protein-protein interaction motif in proteins involved in the DNA damage re...
...BRCA1 gene is involved in sporadic breast and ovarian cancer mainly through reduced expression. BRCA1 mRNAs containing d...
...BRCA1- and BRCA2-mediated tumor suppression as well as cellular viability, we have begun a functional analysis of a defi...
...BRCA1, implicating BARD1 in nuclear targeting of BRCA1 for DNA repair. Our identification of BARD1 as a BRCA1 nuclear ch...
...Brca1 represses tumor formation. To overcome the early lethality, we engineered Brca1 by flanking its exon 11 with loxP ...
...Brca1/2, p53), and gene products of modifier genes. In the mouse model, the most frequently used chemical carcinogen has...
...BRCA1 and BRCA2 (BRCA1/2) genes explain a substantial proportion of hereditary breast and ovarian cancer. Women who have...
...BRCA1 or BRCA2 genes develop their cancers earlier in life (during the premenopausal period), 75-80% of all breast cance...
...BRCA1 and BRCA2 proteins are strongly implicated in HRR; BRCA2 associates with Rad51 and appears to regulate its activit...
...BRCA1, we demonstrate-by direct comparisons-the advantages of CE-LIF over the traditional slab-gel electrophoresis. Thes...
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