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Functions of BRCA1 and BRCA2 in the biological response to DNA damage.

Venkitaraman(A R) J Cell Sci 2002-03-05

Inheritance of one defective copy of either of the two breast-cancer-susceptibility genes, BRCA1 and BRCA2, predisposes ...

Knowledge, attitudes, and interest in breast-ovarian cancer gene testing: a s...

Kinney(A Y),Croyle(R T),Dudley(W N),Bailey... Prev Med 2002-01-30

...BRCA1 mutation.,Interviews were conducted with 95 male and female kindred members to elicit information on sociodemograp...

Evaluation of the needs of male carriers of mutations in BRCA1 or BRCA2 who h...

Liede(A),Metcalfe(K),Hanna(D),Hoodfar(E),S... Am J Hum Genet 2001-01-18

To date, the concerns of men at risk of inheriting a BRCA1 mutation or a BRCA2 mutation have received little attention. ...

Factors associated with decisions about clinical BRCA1/2 testing.

Armstrong(K),Calzone(K),Stopfer(J),Fitzger... Cancer Epidemiol Biomarkers... 2001-03-01

...BRCA1/2 testing. The objective of this study was to determine the factors associated with decisions about clinical BRCA1...

Primary ovarian dysgerminoma in a patient with a germline BRCA1 mutation.

Werness(B A),Ramus(S J),Whittemore(A S),Ga... Int J Gynecol Pathol 2001-04-05

...BRCA1 mutation. Alternatively, such dysgerminomas may be caused by BRCA1 mutations, but occur so infrequently compared w...

Histopathology of familial ovarian tumors in women from families with and wit...

Werness(B A),Ramus(S J),Whittemore(A S),Ga... Hum Pathol 2001-01-04

...BRCA1 mutations, and tumors from BRCA1 mutation-positive families were compared with those from BRCA1-negative families....

The breast surgeon's role in BRCA1 and BRCA2 testing.

Matloff(E T) Am J Surg 2001-01-26

...BRCA1 or BRCA2. Genetic testing is now clinically available, and the results of such testing can dramatically alter a pa...

Uncovering functionally relevant signaling pathways using microarray-based ex...

Harkin(D P) Oncologist 2001-01-03

...BRCA1 tumor-suppressor gene as a means of defining its function. BRCA1 has been implicated in at least three functional ...

Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signalin...

Meng(Q),Yuan(F),Goldberg(I D),Rosen(E M),A... J Nutr 2001-02-01

...BRCA1) synergistically inhibited transcriptional activity of ER-alpha. Moreover, I3C down-regulated the expression of th...

Tamoxifen and breast cancer risk in women harboring a BRCA1 germline mutation...

Eisinger(F),Charafe-Jauffret(E),Jacquemier... Int J Oncol 2001-02-15

...BRCA1-related breast cancers (BRCA1-BCs), and using data on BRCA1-BCs penetrance, as well as compliance and acceptabilit...

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