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Overcoming Resistance to PARP Inhibitors in BRCA-Mutated Cancers: Mechanisms ...

Guo(J),Wang(Y),Li(J),Jiang(Z) J Cancer 2026-00-00

...BRCA1 and BRCA2 are essential for homologous recombination (HR) repair. Mutations in BRCA1/2 compromise HR repair effica...

Prostate cancer germline variants with therapeutic implications.

Bitaraf(M),Castro(E),Sharifi(N) Trends Mol Med 2026-05-00

...BRCA1, BRCA2, and HSD3B1 are the most prevalent alterations in men with advanced prostate cancer and are associated with...

Genomic Landscape of 6597 Hong Kong HBOC Patients: Implications for Beyond-BR...

Kwong(A),Ho(CYS),Tey(SK),Au(CH),Ma(ESK) Int J Mol Sci 2026-08-24

...BRCA1/2. Here we highlight the clinical value of extending testing to beyond BRCA susceptibility genes for improved prev...

Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical ...

Ammous-Boukhris(N),Abdelmaksoud-Dammak(R),... Cancers (Basel) 2026-08-29

...BRCA1/BRCA2 were identified in 19 cases (11.51%), including 8 in BRCA1 and 11 in BRCA2. The presence of BRCA P/LPVs asso...

A low-power LAMP device with chemical heating and compact optical detection f...

Liao(Y),Yamamoto(S),Morioka(K),Yasui(F),Ya... Talanta 2026-01-01

...BRCA1) and synthetic SARS-CoV-2 RNA as model targets. The device exhibited excellent linearity in SYTO-9 fluorescence de...

Hotspots and future trends of male breast cancer: a global perspective.

Hou(J),Feng(H),Zhang(M),Wang(D),Fan(H) Clin Transl Oncol 2026-02-00

...BRCA1/2 gene discoveries. The USA leads in publications and citations, with North America and Europe being the most coll...

Targeting fatty acid synthase to overcome PARP inhibitor resistance and to cr...

Josephraj(S),Wang(CJ),Cui(Q),Dong(Z),Liu(J... Genes Dis 2026-01-00

...BRCA1 expression by inhibiting FASN, contributing to the synergy with PARPi in both BRCA1 wild-type and mutant TNBC cell...

Exploring vulnerable building blocks in protein-protein interaction networks ...

Kumar(S),Agrawal(A),Vindal(V) Comput Biol Chem 2026-02-00

...BRCA1, ERBB2, FN1, FOXA1, JUN, MKI67, and NRAS. Thus, by applying network vulnerability, influence, and gene-disease ass...

Pemetrexed increases BRCA1 protein stability and sensitizes TNBC cells to rad...

Jin(H),Jeon(KH),Kang(C),Lee(J),Lee(Y),Kwon... Oncol Rep 2026-11-00

...BRCA1 deletion mutant analyses suggested that the BRCA1 C‑terminal domain may contribute to the effect of Peme on BRCA1 ...

Case Report: Long-term remission of metastatic pancreatic ductal adenocarcino...

Kolb(H),Hartwig(W),Beyna(T),Auf der Horst(... Front Oncol 2026-00-00

...BRCA1/2, and ERBB2, enables the development of individualized therapeutic strategies. We report here a patient with KRAS...

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