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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irr...

Xu(B),Kim St,Kastan(M B) Mol Cell Biol 2001-06-07

...Brca1, a target for phosphorylation by Atm, abolished the ability of Brca1 to mediate the G(2)/M checkpoint but did not ...

Psychosocial issues following a positive result of genetic testing for BRCA1 ...

Di Prospero(L S),Seminsky(M),Honeyford(J),... CMAJ 2001-05-03

...BRCA1 and BRCA2 genes. The purpose of our study was to explore how genetic testing had affected people found to have a B...

Founder BRCA1 and BRCA2 mutations in early-onset French Canadian breast cance...

Tonin(P N),Perret(C),Lambert(J A),Paradis(... Int J Cancer 2001-05-17

...BRCA1 (n = 4) and BRCA2 (n = 4) were identified in 8 of 61 (13%) cases. All BRCA1 mutations were found in invasive ducta...

More breast cancer genes?

Hopper(J L) Breast Cancer Res 2001-06-28

...BRCA1 and BRCA2 had been excluded, were analyzed using comparative genomic hybridization in order to identify a region o...

Ultraviolet irradiation induces BRCA2 protein depletion through a p53-indepen...

Wang(S C),Makino(K),Su(L K),Pao(A Y),Kim(J... Cancer Res 2001-05-03

...BRCA1 and BRCA2 mRNAs by DNA-damaging agents. Moreover, the proteosome- and calpain-mediated protein degradation pathway...

Color bar coding the BRCA1 gene on combed DNA: a useful strategy for detectin...

Gad(S),Aurias(A),Puget(N),Mairal(A),Schurr... Genes Chromosomes Cancer 2001-06-14

...BRCA1 gene are responsible for the majority of hereditary breast and ovarian cancers. BRCA1 germline mutations, however,...

Apparent human BRCA1 knockout caused by mispriming during polymerase chain re...

Kuschel(B),Gayther(S A),Easton(D F),Ponder... Genes Chromosomes Cancer 2001-06-14

We report an apparent BRCA1 homozygous knockout that, on further analysis, was found to be an artefact of the polymerase...

Colorado family physicians' knowledge of hereditary breast cancer and related...

Mouchawar(J),Klein(C E),Mullineaux(L) J Cancer Educ 2001-07-12

...BRCA1 mutation could pass from father to daughter. Similarly, only half reported an increased ovarian cancer risk for BR...

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breas...

Hashizume(R),Fukuda(M),Maeda(I),Nishikawa(... J Biol Chem 2001-06-28

...BRCA1. Whereas individually BRCA1 and BARD1 have very low ubiquitin ligase activities in vitro, BRCA1 combined with BARD...

Deletion mapping of chromosome segment 11q24-q25, exhibiting extensive alleli...

Gentile(M),Wiman (A),Thorstenson(S),Loman(... Int J Cancer 2001-04-26

...BRCA1 or BRCA2 gene alterations (n = 32, ages 28 to 40 years). Among the consecutive patients, extensive LOH was observe...

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