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TP53 BRCA1 CRISPR single-cell cancer

Joukov(V),Chen(J),Fox(E A),Green(J B),Livi... Proc Natl Acad Sci U S A 2001-12-28

...BRCA1) heterodimerizes with its structural relative, the BRCA1-associated RING domain protein (BARD1), which may have tu...

Mullan(P B),Quinn(J E),Gilmore(P M),McWill... Oncogene 2001-11-01

BRCA1 is a tumour suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. We have gen...

Lahti-Domenici(J),Rapakko(K),Pääkkönen(K),... Cancer Genet Cytogenet 2001-10-04

In the Finnish population, identified mutations in BRCA1 and BRCA2 account for a less than expected proportion of heredi...

Lakhani(S R) Mol Pathol 2001-12-04

...BRCA1 and BRCA2 mutations is discussed.

Kataoka(A),Tada(M),Yano(M),Furuuchi(K),Cor... Am J Pathol 2001-12-04

...BRCA1, APC, hMSH6, and E-cadherin genes, and successfully detected mutations in mRNA and genomic DNA. Because this metho...

Chu(C S),Morgan(M A),Randall(T C),Bandera(... Gynecol Oncol 2001-10-25

...BRCA1.,Patients with ovarian cancer were tested for germline mutations in BRCA1 by polymerase chain reaction amplificati...

Brodie(S G),Deng(C X) Trends Genet 2001-12-12

...Brca1 have been created to study mechanisms underlying BRCA1-associated tumorigenesis. Brca1 is essential in maintaining...

Brzovic(P S),Rajagopal(P),Hoyt(D W),King(M... Nat Struct Biol 2001-10-18

...BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING doma...

Williams(R S),Green(R),Glover(J N) Nat Struct Biol 2001-10-18

The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor fun...

Borg A Semin Cancer Biol 2001-12-07

The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast-ovarian c...

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