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Nilavar(NM),Marin-Gonzalez(A),Menghi(F),Ng... EMBO J 2026-09-18

...Brca1 exon 11. To elucidate how BRCA1 suppresses Group 1 TDs, we analyzed Brca1 coiled-coil (CC)-domain mutants-separati...

Swift(ML),Rogers(CM),Kaur(H),Chowdhury(D),... Nat Rev Mol Cell Biol 2026-09-18

...BRCA1-BARD1 and the 53BP1 axis in repair pathway choice. How RNA-DNA hybrids affect HR execution and how they are proces...

Munir(A),Naseer(N),Koser(T),Khalid(RR) J Biomol Struct Dyn 2026-07-00

...BRCA1/2-mutant cancers that lack homologous recombination repair. In response to DNA breaks, PARP1 triggers an allosteri...

Habano(E),Ogawa(M),Watanabe(K),Akiyama(N),... J Hum Genet 2026-01-00

...BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D) were found in both males (median age: 69) and females (median age: 54). Amon...

Li(Q),Zhou(Z),Li(X),Lan(Q) Noncoding RNA Res 2026-02-00

...BRCA1 expression and DNA damage response were examined by WB, γ-H2AX focus analysis, and the I-SceI-mediated homologous ...

Sutera(P),Van der Eecken(K),Song(Y),Shetty... Eur Urol Oncol 2026-04-00

...BRCA1/2, ATM, and Rb1 are poor prognostic markers in omCSPC. In addition, patients harboring HiRi mutations experienced ...

Zhang(F),Luo(Z),Xiong(Y),Xue(Q),Guo(X),Fu(... Int J Surg 2026-01-01

...BRCA1/2 subgroup, survival benefits were prominent for rPFS (HR 0.32) and OS (HR 0.70). For patients with non- BRCA alte...

Han(Y),Zhou(Q),Dibbs(A),Chen(B),Weiskittel... Int J Radiat Oncol Biol Phy... 2026-02-01

...BRCA1/2 wild-type noncancerous and cancerous cells were treated with PARPi plus photons or protons at the entrance (dose...

Gadomski(SJ),Hughes(KS),Obeid(JS),Rowley(C... JEADV Clin Pract 2026-03-00

...BRCA1, BRCA2, Lynch syndrome genes (MLH1, MSH2, MSH6, PMS2) and other variants (ATM, CDKN2A, FLCN, MITF, POT1, PTEN, TP5...

Di Maggio(F),Togo(G),Pavone(E),Calabrese(A... Clin Chem Lab Med 2026-01-29

...BRCA1 and BRCA2. We identified a total of 7 pathogenic mutations annotated in clinical databases as ClinVar, in BRCA2 (t...