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Gene replacement with the human BRCA1 locus: tissue specific expression and r...

Lane(T F),Lin(C),Brown(M A),Solomon(E),Led... Oncogene 2000-10-02

...BRCA1 locus (TgN x BRCA1GEN). We find that the transgene directs appropriate expression of human BRCA1 transcripts in mu...

Absence of evidence for a familial breast cancer susceptibility gene at chrom...

Rahman(N),Teare(M D),Seal(S),Renard(H),Man... Oncogene 2000-10-02

...BRCA1 or BRCA2. It has been proposed that a further breast cancer susceptibility gene that may account for some of these...

Kinetics of BRCA1 regulation in response to UVC radiation.

Clarkin(C E),Zhang(H),Weber(B L) Cell Mol Life Sci 2000-09-13

...BRCA1 following DNA damage, we exposed MCF-7 cells to increasing doses of ultraviolet C. We observed an increase in BRCA...

BRCA1 partially reverses the transforming activity of the ras oncogene.

Kumar(A),Knott(C),Kuus-Reichel(K),Saedi(M ... Neoplasia 2000-09-06

...BRCA1 was stably expressed in R/R cells under the CMV promoter (R/R-BRCA1). The expression of ras and BRCA1 was confirme...

The BRCA1 C-terminal domain: structure and function.

Huyton(T),Bates(P A),Zhang(X),Sternberg(M ... Mutat Res 2000-11-13

...BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair an...

Comparative genomic hybridization in inherited and sporadic ovarian tumors in...

Patael-Karasik(Y),Daniely(M),Gotlieb(W H),... Cancer Genet Cytogenet 2000-09-08

...BRCA1 mutation carriers and 2 of 8 sporadic cases displayed 9q deletion, and 2 of 3 BRCA1 mutation carriers, but none of...

Repression of the putative tumor suppressor gene Bard1 or expression of Notch...

Soriano(J V),Irminger-Finger(I),Uyttendael... Adv Exp Med Biol 2000-12-01

...Brca1-associated ring domain) is a protein interacting with Brca1 and thought to be involved in Brca1-mediated tumor sup...

An evaluation of needs of female BRCA1 and BRCA2 carriers undergoing genetic ...

Metcalfe(K A),Liede(A),Hoodfar(E),Scott(A)... J Med Genet 2000-12-07

...BRCA1/2 and to determine the impact of receiving a positive BRCA1/2 result. This is the first study to report on a large...

Sequence-specific transcriptional corepressor function for BRCA1 through a no...

Zheng(L),Pan(H),Li(S),Flesken-Nikitin(A),C... Mol Cell 2000-12-07

...BRCA1. ZBRK1 represses transcription through this recognition sequence in a BRCA1-dependent manner. These results thus r...

NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT do...

Ozaki(T),Nagase(T),Ichimiya(S),Seki(N),Ohi... DNA Cell Biol 2000-09-18

...BRCA1 C-terminus) superfamily includes a large number of nuclear proteins closely involved in DNA repair, recombination,...

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