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TP53 BRCA1 CRISPR single-cell cancer

Pierce(L J),Strawderman(M),Narod(S A),Oliv... J Clin Oncol 2000-10-25

Recent laboratory data suggest a role for BRCA1/2 in the cellular response to DNA damage. There is a paucity of clinical...

Gross(E),Arnold(N),Pfeifer(K),Bandick(K),K... Hum Mutat 2000-10-27

...BRCA1 and BRCA2 variations. The BRCA1 and BRAC2 genes display a high proportion of polymorphisms. Sequencing efforts gea...

Kauraniemi(P),Hedenfalk(I),Persson(K),Dugg... Cancer Res 2000-10-27

Comparative genomic hybridization analysis has demonstrated that breast tumors from BRCA1 and BRCA2 germ-line mutation c...

Baldwin(R L),Nemeth(E),Tran(H),Shvartsman(... Cancer Res 2000-10-27

...BRCA1 promoter hypermethylation demonstrated BRCA1 protein expression by immunohistochemistry. BRCA1 methylation was onl...

Le Page(F),Randrianarison(V),Marot(D),Caba... Cancer Res 2000-10-27

...BRCA1 from a recombinant adenovirus fully complements the repair defect in BRCA1-deficient cells. These results represen...

Byrne(T J),Reece(M T),Adams(L A),Hoffman(D... Oncol Rep 2000-11-30

...BRCA1 and BRCA2 (BRCA) mutations in buccal cells. To determine the predictive value of this immunoassay, a double blind ...

McGuire(V),Whittemore(A S),Norris(R),Oakle... Am J Epidemiol 2000-09-27

Ovarian cancer patients who carry germ-line BRCA1 mutations may have improved survival compared with ovarian cancer pati...

Fishman(A),Dekel(E),Chetrit(A),Lerner-Geva... Gynecol Oncol 2000-10-25

The aim of this study was to define the prevalence, clinical characteristics, and BRCA1-2 mutation carrier status of ova...

Allio(T),Preston(R J) Mutat Res 2000-12-28

...Brca1+/- and Brca2+/- human lymphoblasts showed no increased sensitization to BLM in the absence of inhibitor, and diffe...

Hanby(A M),Kelsell(D P),Potts(H W),Gillett... Int J Cancer 2000-11-15

Germline mutations in the breast cancer-associated genes BRCA1 and BRCA2 confer a lifetime risk of malignancy. Distincti...

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