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Tumor suppressor p53 is required to modulate BRCA1 expression.

Arizti(P),Fang(L),Park(I),Yin(Y),Solomon(E... Mol Cell Biol 2000-10-30

...BRCA1 genes. Here we show that BRCA1 expression levels are down-regulated in response to p53 induction in cells that und...

Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 dele...

Rauh-Adelmann(C),Lau(K M),Sabeti(N),Long(J... Mol Carcinog 2000-09-26

Germline mutations of BRCA1 and BRCA2 predispose to hereditary breast, ovarian, and possibly prostate cancer, yet struct...

Screening for genomic rearrangements in families with breast and ovarian canc...

Unger(M A),Nathanson(K L),Calzone(K),Antin... Am J Hum Genet 2000-10-31

...BRCA1 and BRCA2 coding-region mutations had mutations in BRCA1 that were missed by conformation-sensitive gel electropho...

Hereditary breast cancer: a brief overview.

Sng(J H) Ann Acad Med Singapore 2000-12-28

...BRCA1 and BRCA2, amongst others.,In this brief overview, some of the advances in the aetiology of breast cancer will be ...

BRCA1: exploring the links to transcription.

Monteiro(A N) Trends Biochem Sci 2000-12-28

Progress on determining the function of the breast and ovarian cancer susceptibility gene BRCA1 suggests it might be inv...

Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA lev...

Rice(J C),Ozcelik(H),Maxeiner(P),Andrulis(... Carcinogenesis 2000-10-02

...BRCA1 is an important mechanism involved in breast cancer pathogenesis. Mutation is often responsible for BRCA1 inactiva...

Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in bre...

Yoshikawa(K),Ogawa(T),Baer(R),Hemmi(H),Hon... Int J Cancer 2000-09-26

...BRCA1 is rare, BRCA1 protein expression is reduced in about 30% of sporadic breast carcinomas (Yoshikawa et al., Clin. C...

BRCA1 activation of the GADD45 promoter.

Jin(S),Zhao(H),Fan(F),Blanck(P),Fan(W),Col... Oncogene 2000-09-14

...BRCA1. In contrast, both the tumor-derived BRCA1 mutants (p1749R and Y1853insA) and truncated BRCA1 mutant protein (Delt...

Gene replacement with the human BRCA1 locus: tissue specific expression and r...

Lane(T F),Lin(C),Brown(M A),Solomon(E),Led... Oncogene 2000-10-02

...BRCA1 locus (TgN x BRCA1GEN). We find that the transgene directs appropriate expression of human BRCA1 transcripts in mu...

Absence of evidence for a familial breast cancer susceptibility gene at chrom...

Rahman(N),Teare(M D),Seal(S),Renard(H),Man... Oncogene 2000-10-02

...BRCA1 or BRCA2. It has been proposed that a further breast cancer susceptibility gene that may account for some of these...

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