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Familial cancer risks to offspring from mothers with 2 primary breast cancers...

Hemminki(K),Vaittinen(P),Easton(D) Int J Cancer 2000-09-26

...BRCA1 and BRCA2 genes, while the risk of soft tissue and bone sarcomas may reflect the association of these tumours with...

Prevention and therapy for BRCA1/2 mutation carriers and women at high risk f...

Kuschel(B),Lux(M P),Goecke(T O),Beckmann(M W) Eur J Cancer Prev 2000-12-21

...BRCA1 and BRCA2. Germline mutations of the cancer-susceptibility genes BRCA1 and BRCA2 seem to be the major aetiology of...

Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone...

Rice(J C),Futscher(B W) Nucleic Acids Res 2000-10-30

...BRCA1 promoter compared to non-methylated BRCA1 expressing cells. The chromatin of the methylated UACC3199 BRCA1 promote...

Absence of premalignant histologic, molecular, or cell biologic alterations i...

Barakat(R R),Federici(M G),Saigo(P E),Robs... Cancer 2000-08-15

...BRCA1 represents a unique opportunity to search for such premalignant alterations in ovarian tissues that are at unusual...

Roles of BRCA1 and its interacting proteins.

Deng(C X),Brodie(S G) Bioessays 2000-10-06

...BRCA1 predispose women to breast and ovarian cancers. BRCA1 contains several functional domains that interact directly o...

Complex germline rearrangement of BRCA1 associated with breast and ovarian ca...

Payne(S R),Newman(B),King(M C) Genes Chromosomes Cancer 2000-09-20

...BRCA1 predispose to breast and ovarian cancer. Most germline BRCA1 mutations are small insertions, deletions, or single ...

BRCA1, C-erbB-2, and H-ras gene expressions in young women with breast cancer...

Ozer(E),Sis(B),Ozen(E),Sakizli(M),Canda(T)... Appl Immunohistochem Mol Mo... 2000-09-06

...BRCA1 expression was found in five cases (14.3%). Statistical analysis showed that loss of BRCA1 expression was signific...

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin r...

Bochar(D A),Wang(L),Beniya(H),Kinev(A),Xue... Cell 2000-09-14

...BRCA1 is associated with a SWI/SNF-related complex. We show that BRCA1 can directly interact with the BRG1 subunit of th...

Somatic deletions in hereditary breast cancers implicate 13q21 as a putative ...

Kainu(T),Juo(S H),Desper(R),Schaffer(A A),... Proc Natl Acad Sci U S A 2000-09-19

A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We app...

Why are the majority of hereditary cases of early-onset breast cancer sporadi...

Cui(J),Hopper(J L) Cancer Epidemiol Biomarkers... 2000-12-07

...BRCA1 or BRCA2 do not report a family history of the disease. That is, the majority of "hereditary" cases are "sporadic....

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