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TP53 BRCA1 CRISPR single-cell cancer

Scully(R),Ganesan(S),Vlasakova(K),Chen(J),... Mol Cell 2000-01-31

...BRCA1 products were nonfunctional in these assays. These data constitute the basis for a BRCA1 functional assay and sugg...

Kim(S T),Lim(D S),Canman(C E),Kastan(M B) J Biol Chem 2000-02-08

...Brca1, Rad17, PTS, WRN, and ATM (S440) itself. Brca2, phosphatidylinositol 3-kinase, and DNA-5B peptides were phosphoryl...

Johannsson(O),Loman(N),Möller(T),Kristoffe... Eur J Cancer 2000-01-04

We investigated cancer incidence between 1958 and 1995 in 1873 individuals belonging to 29 consecutively identified BRCA...

Jernström(H),Lerman(C),Ghadirian(P),Lynch(... Lancet 2000-02-29

...BRCA1 and BRCA2 germline mutations. We aimed to establish whether pregnancy is a risk factor for hereditary breast cance...

Hamann(U),Sinn(H P) Breast Cancer Res Treat 2000-08-01

...BRCA1 mutation and from one family with strong evidence for linkage to BRCA1 were compared with those of 49 hereditary b...

Pestonjamasp(P H),Mittra(I) J Biosci 2000-08-09

The involvement of the familial breast-ovarian cancer gene (BRCA1) in the molecular pathogenesis of breast cancer among ...

Tõnisson(N),Kurg(A),Kaasik(K),Lõhmussaar(E... Clin Chem Lab Med 2000-09-18

...BRCA1 gene and single nucleotide polymorphism (SNP) chip for genotyping were used as a model system. Chip surface chemis...

Bhattacharyya(A),Ear(U S),Koller(B H),Weic... J Biol Chem 2000-09-07

...Brca1 is involved in recombinational repair of DNA double strand breaks. Using isogenic Brca1(+/+) and brca1(-/-) mouse ...

Niwa(Y),Oyama(T),Nakajima(T) Jpn J Cancer Res 2000-07-18

...BRCA1 in sporadic breast cancers, the relationship between DNA methylation of the BRCA1 promoter region and BRCA1 expres...

Boyd(J),Sonoda(Y),Federici(M G),Bogomolniy... JAMA 2000-05-16

Most hereditary ovarian cancers are associated with germline mutations in BRCA1 or BRCA2. Attempts to define the clinica...

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