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Complex germline rearrangement of BRCA1 associated with breast and ovarian ca...

Payne(S R),Newman(B),King(M C) Genes Chromosomes Cancer 2000-09-20

...BRCA1 predispose to breast and ovarian cancer. Most germline BRCA1 mutations are small insertions, deletions, or single ...

Contralateral breast cancer risk is influenced by the age at onset in BRCA1-a...

Verhoog(L C),Brekelmans(C T),Seynaeve(C),M... Br J Cancer 2000-08-03

BRCA1/2 mutation carriers diagnosed with breast cancer have a strongly elevated life-time risk of developing a contralat...

Simultaneous interdisciplinary counseling in German breast/ovarian cancer fam...

Hofferbert(S),Worringen(U),Backe(J),Rücker... Genet Couns 2000-11-21

...BRCA1/BRCA2 mutation analyses render testing in medium to low risk individuals questionable, our findings emphasize the ...

Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary glan...

Bennett(L M),McAllister(K A),Malphurs(J),W... Cancer Res 2000-08-17

...BRCA1 and BRCA2, are predisposed to the development of breast and ovarian cancer. We used mice with a Brca1 mutation on ...

[Experience at Sheba Hospital in oncogenetic counseling and genetic testing o...

Theodor(L),Shiri-Sverdlov(R),Yechezkel(G H... Harefuah 2000-08-17

...BRCA1 or BRCA2: 67/90 185delAG (BRCA1), 12/90 6174delT (BRCA2), and 4/90 of 5382insC (BRCA1). In addition, a novel mutat...

PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is assoc...

Lechner(M S),Levitan(I),Dressler(G R) Nucleic Acids Res 2000-09-07

...BRCA1 and other nuclear proteins involved in DNA repair/recombination or cell cycle control. Pax2 and PTIP co-localize i...

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage...

Li(S),Ting(N S),Zheng(L),Chen(P L),Ziv(Y),... Nature 2000-08-08

...BRCA1. Here we show that the BRCA1-associated protein CtIP becomes hyperphosphorylated and dissociated from BRCA1 upon i...

Prophylactic mastectomy or screening in women suspected to have the BRCA1/2 m...

Unic(I),Verhoef(L C),Stalmeier(P F),van Da... Med Decis Making 2000-11-29

...BRCA1/2 mutation may choose between two management options: breast cancer screening and prophylactic mastectomy (PM).,To...

Regional methylation of the 5' end CpG island of BRCA1 is associated with red...

Magdinier(F),Billard(L M),Wittmann(G),Frap... FASEB J 2000-08-25

...BRCA1 does not seem to be related to BRCA1 gene alterations. Southern blot analysis and the bisulfite sequencing method ...

Occult ovarian tumors in women with BRCA1 or BRCA2 mutations undergoing proph...

Lu(K H),Garber(J E),Cramer(D W),Welch(W R)... J Clin Oncol 2000-08-01

...BRCA1 and BRCA2 testing, each patient's risk of hereditary predisposition was calculated using the Berry-Parmigiani mode...

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