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Schwartz(CJ),Genco(I),Repetto(M),Muldoon(D... NPJ Breast Cancer 2025-07-22

...BRCA1 (81%, 13/16). Most tumors were grade 3 invasive ductal or metaplastic carcinomas with limited tumor-infiltrating l...

Hachmeriyan(M),Levkova(M),Yahya(D),Stoyano... Oncol Rev 2025-00-00

...BRCA1, MSH2, PALB2, and STK11. These findings underscore the need for enhanced awareness, improved financial access to t...

Lobianco(L),Calvanese(G),D'Ausilio(D),Ross... Cancer Treat Rev 2025-11-00

...BRCA1/2 emerged as a relevant biomarker in PC, linked to aggressive behavior, unfavorable outcomes and notable responses...

Matsuya(S),Tsuchiya(Y),Hiwatashi(Y),Abe(Y)... J Biol Chem 2025-09-00

...BRCA1. In conclusion, our findings indicate that the DSB-induced ATM-dependent phosphorylation of DHX9 at S321, which sh...

Zheng(L),Zhu(Q),Zhang(F),Qiu(H),Qin(L),Yan... Front Oncol 2025-00-00

...BRCA1/BRCA2 GDH. The BRCA1/BRIP1 GDH patient is a 46-year-old female diagnosed with advanced ovarian adenocarcinoma at c...

Wei(X),Mansour(L),Oxley(S),Fierheller(CT),... JAMA Oncol 2025-07-24

...BRCA1/BRCA2/PALB2 pathogenic variants. The precise BC risk threshold for offering risk-reducing mastectomy (RRM) for BC ...

Shohdy(KS),Kassem(L),Elnahas(T),Barsoum(EM... ESMO Open 2025-08-00

...BRCA1/2 sequencing was carried out by target enrichment using the AmoyDx® BRCA1/2 Mutation Kit, and sequencing was carri...

Liu(J),Zhao(C),Chen(J),Zeng(P),Li(Q),Dai(R... Sci Adv 2025-07-25

...BRCA1 mutation. The patient iPSC-MCs recapitulated the transcriptome, clinical genomic alteration, and tumorigenic abili...

Ibrahim(D),Grondin(M),Galpin(K),Asif(S),Th... Front Immunol 2025-00-00

...Brca1-/- and KPCA.B syngeneic mouse models of ovarian cancer, we defined the contribution of TG2 in the TME to the metas...

Liu(XM),Zhu(ZZ),Li(QT),Li(Z),Rong(R),Xie(C... J Med Chem 2025-07-24

...BRCA1-deficient OC via synthetic lethality strategy. Representative compound 4 displayed the most potent antitumor effec...