...BRCA1 products were nonfunctional in these assays. These data constitute the basis for a BRCA1 functional assay and sugg...
...BRCA1 mutation on the basis of tumor phenotype. We found the highest rate of BRCA1 mutations in group A (53%), and low f...
...BRCA1 and BRCA2 mutations in archival paraffin-embedded tumor tissue of four Jewish women with ovarian carcinoma who pre...
...BRCA1 and BRCA2 mutation searches have been performed for 76 of these families; BRCA1 mutations were found in 38 familie...
...BRCA1, BRCA2, and TP53. The proportion of BC in the general population that can be explained by these genes is relativel...
Relative to her risk of breast carcinoma, the woman with a BRCA1 or BRCA2 gene mutation can be managed either by intensi...
...BRCA1, BRCA2), oophorectomy can now be offered specifically to women who are mutation carriers. Conversely, noncarriers ...
...BRCA1 and later BRCA2 testing, Kaiser Permanente began to apply these advances in clinical practice. Recommendations for...
...BRCA1 and BRCA2. Germline mutations in cancer susceptibility genes have been identified in individuals of all races and ...
...BRCA1 gene exhibited LOH on 17q in 3/33 normal clones. One of these clones showed loss of wild-type allele indicating ge...
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