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Clinical impact of molecular genetic diagnosis, genetic counseling, and manag...

Lynch(H T),Watson(P),Shaw(T G),Lynch(J F),... Cancer 2000-01-20

...BRCA1 and BRCA2 mutation searches have been performed for 76 of these families; BRCA1 mutations were found in 38 familie...

Inherited genetic predisposition in breast cancer. A population-based perspec...

Rebbeck(T R) Cancer 2000-01-20

...BRCA1, BRCA2, and TP53. The proportion of BC in the general population that can be explained by these genes is relativel...

Prophylactic mastectomy and inherited predisposition to breast carcinoma.

Hughes(K S),Papa(M Z),Whitney(T),McLellan(... Cancer 2000-01-20

Relative to her risk of breast carcinoma, the woman with a BRCA1 or BRCA2 gene mutation can be managed either by intensi...

Managing hereditary ovarian cancer risk.

Berchuck(A),Schildkraut(J M),Marks(J R),Fu... Cancer 2000-01-20

...BRCA1, BRCA2), oophorectomy can now be offered specifically to women who are mutation carriers. Conversely, noncarriers ...

Breast cancer genetics and managed care. The Kaiser Permanente experience.

Kutner(S E) Cancer 2000-01-20

...BRCA1 and later BRCA2 testing, Kaiser Permanente began to apply these advances in clinical practice. Recommendations for...

Ethnic differences in cancer risk resulting from genetic variation.

Neuhausen(S L) Cancer 2000-01-20

...BRCA1 and BRCA2. Germline mutations in cancer susceptibility genes have been identified in individuals of all races and ...

DNA damage-induced cell cycle checkpoints and DNA strand break repair in deve...

Dasika(G K),Lin(S C),Zhao(S),Sung(P),Tomki... Oncogene 2000-01-20

...BRCA1 and BRCA2 are involved in DNA double-strand break repair (DSBR) and DNA damage-induced checkpoint activation. Many...

BRCA1 deficient embryonic stem cells display a decreased homologous recombina...

Snouwaert(J N),Gowen(L C),Latour(A M),Mohn... Oncogene 2000-01-20

...BRCA1 expression is re-established at 5-10% of normal levels by introduction of a Brca1 transgene into BRCA1 deficient E...

Reduction of BRCA1 expression in sporadic ovarian cancer.

Zheng(W),Luo(F),Lu(J J),Baltayan(A),Press(... Gynecol Oncol 2000-03-21

...BRCA1 by IHC showed low levels of BRCA1 mRNA by RT-PCR.,BRCA1 expression paralleled cell proliferation in benign and bor...

Xp22.2-3 loss of heterozygosity is associated with germline BRCA1 mutation in...

Buekers(T E),Lallas(T A),Buller(R E) Gynecol Oncol 2000-03-21

...BRCA1 mutation. The current study examines the association between X-chromosome LOH and BRCA1 mutation.,Ninety tumor DNA...

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