...BRCA1 gene status was determined by means of single-strand conformational polymorphism analysis and DNA sequencing. All ...
...BRCA1 exon 5. These results demonstrate that RCA offers considerable promise to facilitate effective mutation screening ...
...BRCA1-associated breast cancers appear as high grade, poorly differentiated, highly proliferating, and frequently estrog...
...BRCA1 and BRCA2 germline mutations. Despite the uncertainty, consensus guidelines were defined to assist practitioners',...
...BRCA1 and the other group of 34 breast carcinomas with no allelic loss of BRCA1. The localization of BRCA1 in the 2 grou...
...BRCA1 gene, showed a high proportion of LOH (63%), whereas the intragenic marker for the TP53 gene, HP53, exhibited LOH ...
Most of the hereditary breast cancers are attributed to constitutive alterations of either BRCA1 or BRCA2 genes; nonethe...
...BRCA1 are associated with elevated risk of breast cancer. Evidence for the involvement of Brca1 in cellular differentiat...
...BRCA1 and BRCA2 account for the majority of familial breast cancers. Cells with mutated BRCA1 or BRCA2 are hypersensitiv...
...BRCA1, BRCA2, NFkappaB/IkappaB alpha, beta-adaptin, and perhaps ATM itself. Thus, ATM is a "hierarchical kinase," initia...
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