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Transcription of BRCA1 is dependent on the formation of a specific protein-DN...

Suen(T C),Goss(P E) J Biol Chem 1999-12-16

...BRCA1 expression. To understand transcriptional regulation of the BRCA1 gene, we cloned and examined the BRCA1 promoter,...

Emerging roles of BRCA1 in transcriptional regulation and DNA repair.

Chen(Y),Lee(W H),Chew(H K) J Cell Physiol 1999-11-26

...BRCA1 has intrinsic transactivation activity and is able to activate the p21 promoter. In addition, BRCA1 is linked to a...

A highly accurate, low cost test for BRCA1 mutations.

van Orsouw(N J),Dhanda(R K),Elhaji(Y),Naro... J Med Genet 1999-11-19

...BRCA1 mutations. However, the widespread use of BRCA1 testing has been limited to date by three principal concerns: the ...

Genetic testing for breast cancer predisposition.

Gauthier-Villars(M),Gad(S),Caux(V),Pagès(S... Surg Clin North Am 1999-12-07

...BRCA1 and BRCA2 genes has improved our understanding of the association between breast and ovarian cancers in certain fa...

Brca1 controls homology-directed DNA repair.

Moynahan(M E),Chiu(J W),Koller(B H),Jasin(... Mol Cell 1999-11-26

...BRCA1 confer a high risk of breast and ovarian tumors. The role of BRCA1 in tumor suppression is not yet understood, but...

A systematic review of genetic polymorphisms and breast cancer risk.

Dunning(A M),Healey(C S),Pharoah(P D),Tear... Cancer Epidemiol Biomarkers... 1999-12-10

...BRCA1, COMT, CYP17, CYP1A1, NAT1, and NAT2, the best estimate of risk either from the individual studies or the meta-ana...

Mycoplasma-mediated uptake of the exogenous human BRCA1 gene by hatching blas...

Chan(P J),Brossfield(J E),Patton(W C),King(A) J Assist Reprod Genet 1999-12-15

...BRCA1 DNA into blastocysts.,Hatching mouse blastocysts (N = 70) were incubated in the presence of either viable or dead ...

Is TP53 dysfunction required for BRCA1-associated carcinogenesis?

Schuyer(M),Berns(E M) Mol Cell Endocrinol 1999-12-17

...BRCA1 gene. Although BRCA1 mediates multiple functions in the cell, including a role in DNA damage repair and gene trans...

The influence of familial and hereditary factors on the prognosis of breast c...

Chappuis(P O),Rosenblatt(J),Foulkes(W D) Ann Oncol 1999-12-22

...BRCA1 mutation carriers. This seems to indicate that BRCA1-related breast cancer is not associated with a survival advan...

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage respo...

Cortez(D),Wang(Y),Qin(J),Elledge(S J) Science 1999-12-10

...Brca1 in response to ionizing radiation. ATM resides in a complex with Brca1 and phosphorylated Brca1 in vivo and in vit...

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