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Deugd(R),Riano(JC),de Vries(E),Cardona(AF)... Diseases 2025-07-18

...BRCA1 c.1674del (14.3% germline and 23.7% somatic), BRCA1 c.3331_3334del (33.3% germline and 52.6% somatic), BRCA1 c.512...

Fischer(P),Schmid(M),Ohradanova-Repic(A),S... Cell Death Dis 2025-07-21

...BRCA1-mutated MDA-MB-436 cells, C-ion irradiation was more potent compared to X-rays in inducing the NF-κB-driven immuno...

Rungkamoltip(P),Khongcharoen(N),Nokchan(N)... Int J Mol Sci 2025-07-18

BRCA1 and BRCA2 are associated with advanced prostate cancer progression and poor prognosis. Copy number variants (CNVs)...

Pérez-Rodríguez(ND),Martín-Ramírez(R),Gonz... Biomedicines 2025-07-23

...BRCA1-PALB2-BRCA2 homologous recombination repair complex, are associated with increased risk and aggressiveness of brea...

Liang(R),Luo(M),Yang(X),Luo(B),Liu(R) Cancers (Basel) 2025-07-23

...BRCA1/2 (4.41%) and RAS (4.41%). Patients were categorized into BRAF-like (830 cases), RAS-like (36 cases), high-risk mu...

Katzke(AL),Doebel(M),Hauke(J),Schmidt(G),S... Hum Genomics 2025-07-04

...BRCA1, BRCA2, CDH1, PALB2, PTEN, and TP53. HerediVar offers modular annotation services and allows for collaboration in ...

Yi(H),Zhang(N),Sundquist(J),Sundquist(K),Z... PLoS Med 2025-07-00

...BRCA1/2 pathological mutant status, were not available in our database. Our study suggests that USO reduces the risk of ...

Yusoh(NA),Su(L),Chia(SL),Tian(X),Ahmad(H),... Mol Oncol 2025-11-00

...BRCA1/2-mutant TNBCs via synthetic lethality, most TNBCs are BRCA1/2 wild-type. Synergistic drug combinations may expand...

de Moraes(FCA),Matheus(GTFU),Souza(MEC),Bu... Per Med 2025-08-00

...BRCA1/2 mutations (BRCA1: 14322; BRCA2: 11612). BRCA1 and BRCA2 mutations were significantly associated with increased g...

Wang(CC),Duan(J),Mao(ND),He(M),Zhang(PP),Y... Biochem Pharmacol 2025-11-00

...BRCA1/2) mutations compared to naïve patients. Preclinical studies suggested that combination therapy using PARPi and AT...