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Recent advances in breast cancer biology.

Schultz(L B),Weber(B L) Curr Opin Oncol 1999-12-03

...BRCA1, as has our knowledge of the role of the ATM gene and predisposition to breast cancer in ataxia-telangiectasia car...

Accumulation of p53 protein is frequent in ovarian cancers associated with BR...

Zweemer(R P),Shaw(P A),Verheijen(R M),Ryan... J Clin Pathol 1999-11-16

...BRCA1 and BRCA2 germline mutations. BRCA1 related ovarian cancers showed p53 accumulation in 22 of 30 cases (73%); p53 a...

Breast cancer: genetic predisposition and exposure to radiation.

Bennett(L M) Mol Carcinog 1999-12-02

...BRCA1, BRCA2, ATM, and p53, has been accompanied by the examination of the effects of radiation in combination with gene...

Characterization of the human Rad51 genomic locus and examination of tumors w...

Schmutte(C),Tombline(G),Rhiem(K),Sadoff(M ... Cancer Res 1999-10-08

Human Rad51 (hRad51) has been found to be associated with BRCA1, BRCA2, and p53 either directly or indirectly and is one...

Different profiles of allelic losses in cervical carcinoma cases in Surinam a...

Krul(E J),Kersemaekers(A M),Zomerdijk-Nooy... Cancer 1999-10-05

...BRCA1]) and at chromosomes 3p, 6p, 6q, and 11q, which frequently are lost in cervical carcinoma.,Remarkable differences ...

BRCA1 mutation analysis in 83 Spanish breast and breast/ovarian cancer families.

Díez(O),Cortés(J),Domènech(M),Brunet(J),De... Int J Cancer 1999-11-18

A group of 83 Spanish BC/OC families were analysed for BRCA1 germ-line mutations. Analysis of the entire coding sequence...

Characterization of the BRCA1-like immunoreactivity of human seminal plasma.

Angelopoulou(K),Borchert(G),Melegos(D N),L... Urology 1999-11-05

...BRCA1 protein. Our objective was to characterize the BRCA1-like immunoreactivity that is detected in human seminal plasm...

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

Lorick(K L),Jensen(J P),Fang(S),Ong(A M),H... Proc Natl Acad Sci U S A 1999-10-21

...BRCA1, Siah-1, TRC8, NF-X1, kf-1, and Praja1, were assessed for their ability to facilitate E2-dependent ubiquitination....

Population-based estimate of the average age-specific cumulative risk of brea...

Hopper(J L),Southey(M C),Dite(G S),Jolley(... Cancer Epidemiol Biomarkers... 1999-11-10

...BRCA1 and 9 BRCA2), only 5 (1 BRCA1 and 4 BRCA2) had at least one affected relative, so family history of breast cancer ...

Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind stran...

Yamane(K),Tsuruo(T) Oncogene 1999-10-21

The BRCT region, the carboxyl-terminus of BRCA1 (the breast cancer susceptibility gene 1 product), is a ubiquitous regio...

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