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TP53 BRCA1 CRISPR single-cell cancer

Chen(J J),Silver(D),Cantor(S),Livingston(D... Cancer Res 1999-04-22

The two major hereditary breast cancer susceptibility genes, BRCA1 and BRCA2, are associated with early-onset breast and...

Janezic(S A),Ziogas(A),Krumroy(L M),Krasne... Hum Mol Genet 1999-06-23

...BRCA1 ) germline alterations in the ovarian cancer population. To achieve this, we determined the prevalence of BRCA1 al...

Chodosh(L A),D'Cruz(C M),Gardner(H P),Ha(S... Cancer Res 1999-04-22

...BRCA1 and BRCA2, in the normal differentiation and development of the breast; studying the function of three novel prote...

Li(S),Chen(P L),Subramanian(T),Chinnadurai... J Biol Chem 1999-05-17

...BRCA1 to transactivate the p21 promoter can be inactivated by mutation of the conserved BRCA1 C-terminal (BRCT) repeats....

Xu(X),Weaver(Z),Linke(S P),Li(C),Gotay(J),... Mol Cell 1999-04-26

...Brca1 tumor suppressor gene predispose women to breast and ovarian cancers. To study mechanisms underlying BRCA1-related...

Rebbeck(T R),Kantoff(P W),Krithivas(K),Neu... Am J Hum Genet 1999-05-20

Compared with the general population, women who have inherited a germline mutation in the BRCA1 gene have a greatly incr...

Liu(X),Barker(D F) Am J Hum Genet 1999-05-20

...BRCA1 pseudogene, NBR2, and BRCA1 in a tandemly duplicated structure. A series of biallelic polymorphisms define two com...

Eisinger(F),Alby(N),Bremond(A),Dauplat(J),... Ann Genet 1999-05-18

Almost 10% of breast and ovarian cancer are inherited, and the majority are linked to BRCA1 and BRCA2 germline mutations...

Schuyer(M),Berns(E M) Mol Cell Endocrinol 1999-12-17

...BRCA1 gene. Although BRCA1 mediates multiple functions in the cell, including a role in DNA damage repair and gene trans...

Chappuis(P O),Rosenblatt(J),Foulkes(W D) Ann Oncol 1999-12-22

...BRCA1 mutation carriers. This seems to indicate that BRCA1-related breast cancer is not associated with a survival advan...

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