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CRISPR-Cas9-mediated homology-directed repair rescues the induced bone marrow...

Harikrishnan(H),Lamsal(M),Chan(KK),Zhang(J... Mol Ther Nucleic Acids 2026-06-16

...Fancc cDNA into its endogenous locus while minimizing off-target effects and AAV integration. Correction of Fancc -/- HS...

Uncovering Hereditary Risk: Germline Homologous Recombination Repair Variant ...

Kapoor(A),Uthale(S),Chain(A),Rungta(A),Ano... JCO Glob Oncol 2026-08-00

...FANCC. Of 950 patients analyzed, 364 (38.3%) harbored variants in HRR genes, with 266 (28%) carrying pathogenic/likely p...

Fanconi anemia complementation group C gene (FANCC) association with heredita...

Desai(D),Sager(RA),Basin(M),Jacob(JM),Morr... Oncologist 2026-02-05

...FANCC: SUSD3, FANCC: FANCC, and FANCC: C20orf24). Interestingly, 14 (52%) of the FANCC-mutated RT were predicted to be g...

Whole genome sequencing approach to assess homologous recombination deficienc...

Al Assaad(M),Hadi(K),Levine(MF),Guevara(D)... Commun Med (Lond) 2026-01-12

...FANCC, and deleterious structural variants. In a subset of cases, the whole genome sequencing-based classifier offers mo...

Fanconi Anemia in Mexican Patients: Molecular Spectrum and Clinical Manifesta...

Flores-Leura(FA),Brukman-Jiménez(SA),Coron... Int J Mol Sci 2026-04-30

...FANCC (14.3%, n = 2), and FANCE (7.1%, n = 1), with a relatively balanced distribution of homozygous (57.1%, n = 8) and ...

Activation of GLP-1R ameliorates microglial pyroptosis after spinal cord inju...

Li(G),Luo(Y),Zhu(T),Chen(C),Qian(Z),Li(H) Brain Behav Immun 2026-05-00

...FANCC) to suppress pyroptosis. Crucially, FANCC knockdown both elevated p38 phosphorylation and blocked the anti-pyropto...

Gene by environment interaction effects on the metabolic subtype of Polycysti...

Gardner(HR),Meyer(ML),Wagner(JK),Perreira(... Front Genet 2026-00-00

...FANCC on PCOS, and diet and a variant near CMAS on both PCOS and mPCOS. We also detected GxE interactions between anxiet...

Integrated single-cell and spatial transcriptomics uncover the prognostic, ep...

Zhang(Z),Sha(Z),Liu(H),Chen(Y),Liu(Z),Chen... Neurol Res 2026-08-00

...FANCC) as a novel immune checkpoint regulator given its spatial correlation with tumor microenvironments and clinical as...

Predictive genomic medicine enlarges the spectrum of predisposing mutations f...

Di Maggio(F),Togo(G),Pavone(E),Calabrese(A... Clin Chem Lab Med 2026-01-29

...FANCC genes (approximately 12.5 % of our patients). The results show a frequent predisposition to head and neck tumors s...

Potential role of Fanconi anemia pathway in the pathogenesis of endometrial c...

Yao(M),Liu(C),Ping(H),Meng(K),Li(X),Li(Q),... Mol Med Rep 2025-11-00

...FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, FANCN/PALB2, FANCO/RAD51C, FANCP/SLX...

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