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Break-induced replication is enhanced by a phospho-activated RPA-binding modu...

Jones(D),Appanah(R),Yates(LA),Oliver(AW),R... Nat Commun 2026-04-09

...FANCM helicase and BIR antagonist Mph1. This implies a key role for RPA in the dynamic orchestration of the enzymes medi...

Chronic replication stress-mediated genomic instability disrupts placenta dev...

Munisha(M),Huang(R),Khan(J),Schimenti(JC) PLoS Genet 2026-04-00

...FANCM, a protein involved in replication-associated DNA repair, also had placentae with a diminished JZ. These findings ...

Defective BRCA1-mediated DNA end resection drives tandem duplication formatio...

Nilavar(NM),Marin-Gonzalez(A),Menghi(F),Ng... bioRxiv 2026-02-20

...Fancm deletion is well-tolerated by Brca1 CC mutant mES cells. Thus, Group 1 TD formation and Fancm synthetic lethality ...

Predisposition to ALL and Solid Tumors Rather Than Bone Marrow Failure in FAN...

Pegoraro(F),Larcher(L),Kim(R),Pagès(M),Pas... JCO Precis Oncol 2026-03-00

...FANCM patients with FA (P < .0001). The treatment courses of the two FANCM-related ALL cases are reported. Biallelic FAN...

Genomic characterization of resistant and relapsed adult B-cell acute lymphob...

Płotka(A),Marcinkowska-Swojak(M),Rakoczy(M... J Appl Genet 2026-03-26

...FANCM), kinase signaling (JAK2, NF1), and chromatin remodeling (CREBBP, BARD1), as well as the gene ontology term “regul...

Real-World Germline Testing Patterns and Clinical Implications of HRR-Associa...

Abad(CB),Deza(DC),Campillo(FM),Fuente(NP),... Cancers (Basel) 2026-08-11

...FANCM, variants with potential therapeutic relevance. Of these 20 patients, 11 (55.0%) received matched therapy, and tre...

Disulfide engineering of the FANCM-MHF complex reveals constraints on crossli...

Ito(S),Nishino(T) Protein Sci 2026-09-00

...FANCM from the FANCM-associated histone fold (MHF) heterotetramer under crystallization conditions. Here, we used struct...

CHAMP1 complex promotes heterochromatin assembly and reduces replication stress.

Li(F),Elbakry(A),Zhou(FY),Zhang(T),Ravindr... Proc Natl Acad Sci U S A 2026-01-06

...FANCM inhibition in ALT-positive tumor cells, and the CHAMP1 complex is essential for the survival of CCNE1-amplified ov...

[Characteristics of uterine leiomyosarcoma: a clinicopathological and molecul...

Li(XY),Liu(CR) Zhonghua Bing Li Xue Za Zhi 2026-01-08

...FANCM, RAD51B, BARD1, FANCE, ATM, CHEK2 etc. Thirteen cases showed loss of ATRX protein expression. Conclusions: Uterine...

Crossover control: A key to unlocking genetic diversity in plant breeding.

Park(J),Kbiri(N),Choi(K) J Integr Plant Biol 2026-08-00

...FANCM and RECQ4, the pro-crossover factor HEI10, and heterochromatin-organizing proteins-that can modulate crossover fre...

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