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Energetically equivalent structural transitions in the Rad17-Rad9-Hus1-Rad1-Rhi…

Fukumoto(Y),Yuki(R),Ogra(Y) Nucleic Acids Res 2026-02-05

...Rad17, Rad9-Hus1-Rad1 (9-1-1), and Rhino during ATR-DDR progression. Biochemical and computational analyses revealed the...

Rad1-Rad10 uses different interfaces to interact with pathway-specific DNA repa…

Rodríguez González(J),Herman(OT),Lewis(KE),M… Nucleic Acids Res 2026-09-07

...Rad1-Rad10-Saw1 complex at 3.7 Å resolution. The structure reveals that Saw1 wraps around the helicase-like domain of Ra...

A RHNO1-ATR/Chk1 positive feedback loop sustains the DNA replication stress res…

Jirapongwattana(N),Conover(CM),Trujillo Jara… bioRxiv 2026-06-12

...RAD1 interacting nuclear orphan 1 (RHNO1) in cancer progression and its involvement in maintaining ATR/Chk1 signaling du...

CTPS1 is an unexplored vulnerability in breast and ovarian cancer.

Wang(X),Emch(MJ),Voll(LA),Epp(R),Rodman(EPB)… Theranostics None

...RAD1, RAD9A, and RHOA) were identified as potential TNBC selective dependencies. Among these, CTPS1 was prioritized for ...

RAD1 promotes oxaliplatin resistance in gastric cancer by reinforcing NRF2-driv…

Zhou(B),Zhang(S),Shen(Z),Si(Y),Luo(T),Shen(H… Drug Resist Updat 2026-07-00

...RAD1) was further validated using public protein data, an independent neoadjuvant cohort assessed by tumor regression, a...

A point mutation in the FAT domain constitutively increases the kinase activity…

Dev(K),Rider(SD),Singh(B),Saini(A),Xu(YJ) PLoS Genet 2026-06-00

...Rad1-Hus1 (9-1-1) complex specifically in the DNA replication checkpoint, not the damage checkpoint pathway. Since the m...

YOLO26x-based automated fracture detection on radiographs and its impact on rad…

Pamuk(GG),Yüce(M),Öztürk(S),İşleyen(ME),Kara… Eur J Radiol 2026-10-00

...RAD1: 76.2 % → 83.4 %, p = 0.001; RAD3: 75.6 % → 83.4 %, p < 0.001; Holm-corrected), with sensitivity gains of 2.4-16.4 ...

Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard rep…

Segura-Bayona(S),Maric(M),Takaki(T),Manova(Z… Nat Struct Mol Biol 2026-07-00

...RAD1 (9-1-1) clamp in ATRX-deficient cells. ATRX-CST synthetic lethality manifests following accumulation of telomeric G...

Construction of a novel signature based on CRISPR-Cas9 screening for prognostic…

Xiao(WT),He(JY),Yang(D),Xun(Y) BMC Cancer 2026-05-14

...RAD1, RBBP8, TUBA1B, and VPS28) was developed. This signature effectively stratified patients into high- and low-risk gr...

The telomere-binding protein KU is required for DSB repair in rice mitosis but …

Zhao(Y),Wang(B),Pang(Y),You(H),Cao(L),Zhong(… New Phytol 2026-07-00

...rad1) nor genetically interacted with key HR factors (ZIP4 and MER3). Taken together, our findings establish rice meiosi...

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