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Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation-Informed P…

Chen(H),Zhao(Y),Hu(B),Wang(W),Song(M),Zhao(A… Adv Sci (Weinh) 2026-06-00

...RAD51C, and BAP1), establishing a generalizable framework for gene-specific VEP with potential applications in precision...

KAT2B-mediated epigenetic suppression of RAD51C enhances olaparib sensitivity i…

Liu(X),Chen(J),Shen(X),Li(L) Cancer Chemother Pharmacol 2026-03-14

...RAD51C, reducing the expression of RAD51C by lowering the acetylation of histone H3 (H3K27) at the promoter of RAD51C. W...

[Hereditary breast cancer : Syndromes, pathology, clinical aspects].

Lebeau(A),Schmutzler(R) Pathologie (Heidelb) 2026-09-00

...RAD51C/D, BARD1) and genes associated with classic tumor predisposition syndromes (TP53, PTEN, STK11, CDH1, NF1) are ass...

Risk-reducing gynecologic surgery in non-BRCA cancer predisposition mutations: …

Mubeen(A),Dhall(D),Sharma(AE) Int J Gynecol Cancer 2026-08-07

...RAD51C, RAD51D, BRIP1, CHEK2, BARD1, and ATM) or in BRCA1/2 who underwent risk-reducing salpingectomy or salpingo-oophor...

Spatiotemporal regulation of DNA repair proteins between Golgi and nucleus main…

Galea(G),Kuodyte(K),Khan(MM),Thul(PJ),Neuman… J Cell Biol 2026-09-07

...RAD51C, we show that DNA damage triggers ataxia telangiectasia mutated (ATM)-dependent release of a giantin-tethered Gol...

Characterization of putative germline pathogenic variants in 27 candidate cance…

Ikeda(N),Mizukami(K),Yamada(R),Toyoda(H),Aoi… Sci Rep 2026-08-08

...RAD51C, or ATM) and two cats with those in mismatch repair genes (MSH2 and MSH6) may be candidates for targeted therapy ...

From genetic testing to prevention: an integrated clinical pathway for heredita…

Viveros-Carreño(D),Mora-Soto(N),Beshar(I),Ag… Int J Gynecol Cancer 2026-08-03

...RAD51C, RAD51D, PALB2, and selected rare histology-directed syndromes require distinct counseling. Gene-specific penetra...

RAD51C breast cancer-identified variants with attenuated homologous recombinati…

Ganesan(GS),Moosbrugger(ZR),Parker(PS),Goff(… NAR Cancer 2026-09-00

...RAD51C is essential for DNA double-strand break repair through the homologous recombination (HR) pathway. RAD51C loss is...

PARP Inhibitor Sensitivity in Tumors Harboring Non-BRCA Homologous Recombinatio…

Dos Santos(ES),Cicilini(AL),Simões(MFE),Baz(… Int J Mol Sci 2026-07-28

...RAD51C and RAD51D also showed clinically meaningful activity, particularly in ovarian cancer. In contrast, evidence supp...

How Often are druggable mutations detectable in Metastatic Castration Resistant…

Steenbock(O),Rieger(C),Heidenreich(J),Paffen… Urol Int 2026-08-13

...RAD51C, TP53, Wnt-Pathway). Since 2023, we applied the TSO500 panel in selected cases. The HRD score was calculated by c...

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