...RAD51C, and BAP1), establishing a generalizable framework for gene-specific VEP with potential applications in precision...
...RAD51C, reducing the expression of RAD51C by lowering the acetylation of histone H3 (H3K27) at the promoter of RAD51C. W...
...RAD51C/D, BARD1) and genes associated with classic tumor predisposition syndromes (TP53, PTEN, STK11, CDH1, NF1) are ass...
...RAD51C, RAD51D, BRIP1, CHEK2, BARD1, and ATM) or in BRCA1/2 who underwent risk-reducing salpingectomy or salpingo-oophor...
...RAD51C, we show that DNA damage triggers ataxia telangiectasia mutated (ATM)-dependent release of a giantin-tethered Gol...
...RAD51C, or ATM) and two cats with those in mismatch repair genes (MSH2 and MSH6) may be candidates for targeted therapy ...
...RAD51C, RAD51D, PALB2, and selected rare histology-directed syndromes require distinct counseling. Gene-specific penetra...
...RAD51C is essential for DNA double-strand break repair through the homologous recombination (HR) pathway. RAD51C loss is...
...RAD51C and RAD51D also showed clinically meaningful activity, particularly in ovarian cancer. In contrast, evidence supp...
...RAD51C, TP53, Wnt-Pathway). Since 2023, we applied the TSO500 panel in selected cases. The HRD score was calculated by c...
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