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DCC

Gene name:DCC netrin 1 receptor

...DCC基因突变或表达缺失与多种癌症密切相关,尤其是结直肠癌,其名称正是源于在结直肠癌中常发现该基因的缺失。突变可能导致DCC功能丧失,破坏细胞正常凋亡过程,促进肿瘤发生。DCC表达降低还与胃癌、胰腺癌等恶性肿瘤进展相关。过表达DCC可抑制肿...

IGDCC4

Gene name:immunoglobulin superfamily DCC subclass member 4

...DCC4(Immunoglobulin superfamily DCC subclass member 4)属于免疫球蛋白超家族(IgSF)中的DCC亚类成员,是一类跨膜蛋白基因家族。该家族成员通常具有细胞黏附和信号传导功能,其结构特点是含...

IGDCC3

Gene name:immunoglobulin superfamily DCC subclass member 3

...DCC3(Immunoglobulin superfamily DCC subclass member 3)属于免疫球蛋白超家族(IgSF)中的DCC亚类基因家族,该家族还包括DCC(Deleted in Colorectal Carcin...

APPL1

Gene name:adaptor protein, phosphotyrosine interacting with PH d…

APPL1(Adaptor Protein, Phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1)是一种多功能衔接蛋白,在细胞信号转导、代谢调控和细胞...

NEO1

Gene name:neogenin 1

...DCC家族其他成员(如DCC和UNC5)功能重叠,但具有独特的配体偏好性,例如对RGM的亲和力更高。在疾病中,NEO1的表达水平变化可能影响其他基因(如Netrin通路相关基因)的功能,进而改变细胞黏附或凋亡进程。研究还发现,NEO1在炎症...

PRTG

Gene name:protogenin

PRTG(也称为Piezo-Type Mechanosensitive Ion Channel Component 2或PIEZO2)是一种机械敏感性离子通道蛋白,属于Piezo基因家族。这个家族包括PIEZO1和PIEZO2两个成员,它们...

APPL2

Gene name:adaptor protein, phosphotyrosine interacting with PH d…

APPL2(Adaptor Protein, Phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2)是一种衔接蛋白,属于APPL基因家族,该家族还包括A...

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