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Wang(Z),Jin(M),Zhai(L),Huang(B),Jin(X),Wan... Mol Cell 2026-02-19

...BRCA2 interaction, impairs RAD51 foci formation, and suppresses HR. Upon DNA damage, ATM-dependent phosphorylation of HD...

Sims(TT),Sood(AK),Westin(SN),Rangel(K),Fle... Int J Gynecol Cancer 2026-07-00

...BRCA2 mutation or have tumors characterized by homologous recombination deficiency (HRD). We hypothesized that germline ...

Chen(M),Dong(Y),Wang(R),Cui(H) Ann Ital Chir 2026-02-09

...BRCA2) are core regulators of the DNA damage homologous recombination repair (HRR) pathway, and their pathogenic mutatio...

Cylwik(D),Dwornik(R),Białkowska(K) Cancers (Basel) 2026-01-23

...BRCA2 genes, which are major contributors to hereditary susceptibility to this malignancy. Although PV carriers have hig...

Kulikowska(B),Panasiuk(B),Posmyk(R) Cancers (Basel) 2026-02-02

...BRCA2 genes are particularly notable, especially in certain populations where founder mutations (specific genetic varian...

You(Q),Gong(L),Chen(Y),Dinglin(X),Cheng(Z)... Front Oncol None

...BRCA2 mutations exhibited an exceptional response to adjuvant therapy with olaparib. Personalized ctDNA monitoring, util...

Hale(A),Lynch(KA),Dhoonmoon(A),Nicolae(CM)... NAR Cancer 2026-03-00

...BRCA2-deficient cells. We also show that these domains are essential for replication stress-induced double-strand break ...

Aranda-Gutierrez(A),Villarreal-Garza(C),Ag... Patient Educ Couns 2026-06-00

...BRCA2 (25.7 %). The mean knowledge score was 9.42 out of 16 (SD 3.0), with item-level gaps most pronounced in inheritanc...

Liu(J),Zhang(X),Lu(HX),Li(XY),Guo(YH),Zhon... Zhonghua Zhong Liu Za Zhi 2026-02-23

...BRCA2 mutation rate at 6.06% (8/132). Compared with the BRCA wild-type group, the BRCA mutation group exhibited smaller ...

Ökten(IN),Baydaş(T),Koca(S),Baltacı(MF),Öz... BMC Cancer 2026-02-13

Germline testing for BRCA1 and BRCA2 has become integral to the management of breast cancer, with pathogenic variants st...