Renal cell carcinoma (RCC) associated with BRCA2 mutation is an extremely rare but increasingly recognized tumor type wi...
...BRCA2, CASP2, MYC, MDM2, CDKN1A, ERCC1, ATR, and PRKDC were quantified through qPCR using the ΔΔCt method. Molecular doc...
...BRCA2 knockout) A549 and HCT116 cell lines, and pharmacologic inhibitors of ATM and PARP using KU55933 or AZD1390 and ol...
...BRCA2, a diagnosis of ovarian cancer, and no other cancer history and no risk-reducing bilateral mastectomy. Women were ...
...BRCA2:c.67 G > C (p.D23H, NM_000059.4) had remained unclear. Functional analysis demonstrated exon 2 skipping consistent...
...BRCA2(1S)_Pos1, BRCA2(1S)_Pos7, and RAD51D_Pos6-were identified as independent predictors of PARPi sensitivity. The logi...
...BRCA2. This study demonstrates poor facility-level adherence with MSI/MMR testing recommendations and poor patient-level...
...BRCA2, PALB2, CHEK2, and ATM PV carriers. We estimated pooled hazard ratios (HRs) in meta-analyses using the generic inv...
...BRCA2 mutations in responders, whereas non-responders harbored clonal FGFR3 mutations. Limitations include small sample ...
...BRCA2). Notably, many of the identified variants were classified as Variant of Uncertain Significance (VUS) or likely be...
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