...BRCA2 are specifically involved in the homologous recombination repair (HRR) of DNA double-strand breaks. A central play...
...BRCA2 mutation carriers. For ovarian cancer, the risk estimates are in the range of 22-65% for BRCA1 and 10-35% for BRCA...
...BRCA2 account for about 25-28% of these cases. For the remainder, several genes of moderate and low penetrance have been...
...BRCA2 mutations were observed in two tumors, with nine showing evidence of a homologous recombination (HR) defect. Combi...
...BRCA2 susceptibility genes. The case is interesting because of the rarity of the histological variant, the young age of ...
...BRCA2 single nucleotide polymorphism in homozygosis. In this family, the mutation c.1849G>A in the CDH1 gene is not rela...
...BRCA2, BRCA1, and ATM were observed at substantially higher frequencies (19.3% overall) compared to those in primary pro...
...BRCA2 screening of all women regardless of risk status. Both proposed genetic screening tests raise complicated issues r...
...BRCA2 mutations is widely recommended as part of a risk-reduction strategy for ovarian or breast cancer due to an underl...
...BRCA2 in hereditary breast and ovarian cancer syndrome. The genetic background in families with hereditary breast cancer...
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