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Skin-sparing mastectomy.

González(Eduardo G),Rancati(Alberto O) Gland Surg 2015-12-08

...BRCA2 mutations, and also due to new staging standards and use of nuclear magnetic resonance. This increase in the indic...

Double Heterozygosity of BRCA2 and STK11 in Familial Breast Cancer Detected b...

Ataei-Kachouei(Mojgan),Nadaf(Javad),Akbari... Iran J Public Health 2015-11-20

...BRCA2) can be involved in pathogenesis of hereditary breast cancer which can be explained by incomplete penetrance of BR...

A phase II evaluation of the potent, highly selective PARP inhibitor velipari...

Coleman(Robert L),Sill(Michael W),Bell-McG... Gynecol Oncol 2015-09-01

...BRCA2. We studied the clinical activity and toxicity of veliparib in ovarian cancer patients carrying a germline BRCA1 o...

Phenotypic analysis of familial breast cancer: comparison of BRCAx tumors wit...

Aloraifi(F),Alshehhi(M),McDevitt(T),Cody(N... Eur J Surg Oncol 2015-06-22

...BRCA2 negative familial breast cancer (BRCAx) to BRCA1-positive, BRCA2-positive and sporadic cases without a family hist...

Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome rem...

Guillemette(Shawna),Serra(Ryan W),Peng(Min... Genes Dev 2015-04-22

...BRCA2 show de novo loss of CHD4 expression in vitro. Moreover, BRCA2 mutant ovarian cancers with reduced CHD4 expression...

Lipid and Metabolite Deregulation in the Breast Tissue of Women Carrying BRCA...

Ramadan(Saadallah),Arm(Jameen),Silcock(Jud... Radiology 2015-08-06

...BRCA2 cohorts showed a 47% (P = .002) increase in cholesterol level in the BRCA2 cohort when compared with diallylic lip...

BRCA1 and BRCA2 common mutations in iranian breast cancer patients: a meta an...

Forat-Yazdi(Mohammad),Neamatzadeh(Hossein)... Asian Pac J Cancer Prev 2015-12-08

...BRCA2 associated with breast cancer have been reported in different populations. However, the common BRCA1 and BRCA2 mut...

Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk ...

Walsh(Christine S) Gynecol Oncol 2015-08-24

Almost exactly 20 years after their discovery, the BRCA1 and BRCA2 genes have become the target of the first "personaliz...

Whole genomes redefine the mutational landscape of pancreatic cancer.

Waddell(Nicola),Pajic(Marina),Patch(Ann-Ma... Nature 2015-04-15

...BRCA2 or PALB2) and a mutational signature of DNA damage repair deficiency. Of 8 patients who received platinum therapy,...

The prevalence of BRCA1 and BRCA2 mutations among young Mexican women with tr...

Villarreal-Garza(C),Weitzel(J N),Llacuacha... Breast Cancer Res Treat 2015-12-04

...BRCA2 (BRCA) mutations among 190 women with triple-negative breast cancer, unselected for family history, diagnosed at a...

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