Specific germline mutations in the hereditary breast-ovarian cancer susceptibility (HBC/HBOC) genes, BRCA1, BRCA2 and PA...
...BRCA2 are specifically involved in the homologous recombination repair (HRR) of DNA double-strand breaks. A central play...
...BRCA2, we used T cell-specific conditional Brca2 knockout mice, which were previously shown to develop thymic lymphoma a...
...BRCA2 were amplified and sequenced by next-generation sequencing. We identified a BRCA1 or BRCA2 mutation in 74 of 774 (...
...BRCA2 genes. Total RNA was analyzed for the presence of BRCA1 and BRCA2 naturally occurring and pathological transcripts...
...BRCA2 genes, are sensitive to PARP inhibition. Microsatellite instability (MSI) accounts for 10-15% of colorectal cancer...
...BRCA2 mutation carriers. For ovarian cancer, the risk estimates are in the range of 22-65% for BRCA1 and 10-35% for BRCA...
...BRCA2 account for about 25-28% of these cases. For the remainder, several genes of moderate and low penetrance have been...
...BRCA2 single nucleotide polymorphism in homozygosis. In this family, the mutation c.1849G>A in the CDH1 gene is not rela...
...BRCA2 mutations were observed in two tumors, with nine showing evidence of a homologous recombination (HR) defect. Combi...
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