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Long-term prospective clinical follow-up after BRCA1/2 presymptomatic testing...

Evans(D Gareth),Harkness(Elaine),Lalloo(Fi... J Med Genet 2015-11-05

...BRCA2. Breast cancer incidence for BRCA2 was marginally higher than BRCA1 at 20.05 per 1000 in BRCA2 compared with 16.20...

BRCA2 and RAD51 promote double-strand break formation and cell death in respo...

Jones(Rebecca M),Kotsantis(Panagiotis),Ste... Mol Cancer Ther 2015-05-12

...BRCA2. Here, we investigate why, paradoxically, mutations in HR genes protect cells from killing by gemcitabine. Using D...

Personalized prostate cancer screening among men with high risk genetic predi...

Margel(David),Benjaminov(Ofer),Ozalvo(Rach... BMC Cancer 2015-02-27

...BRCA2 germ line mutation. They will be identified via our Genetic counseling unit. All men after signing an informed con...

[Hereditary predisposition to cancers of the digestive tract, breast, gynecol...

Turpin(Anthony),Cattan(Stéphane),Leclerc(J... Bull Cancer 2015-03-27

...BRCA2 mutations (cumulative incidence of 45%). Gynecological and gonadal tumors are frequent as well and can be more (ad...

Analysis of novel mutations in BRCA1 in Iranian families with breast cancer.

Sadr-Nabavi(Ariane),Dastpak(Mahtab),Homaei... Hereditas 2015-04-06

...BRCA2 genes. Some recent studies demonstrated that BRCA1 mutations are seen in high-risk women with family histories of ...

Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.

Simhadri(Srilatha),Peterson(Shaun),Patel(D... J Biol Chem 2015-01-22

PALB2 links BRCA1 and BRCA2 in homologous recombinational repair of DNA double strand breaks (DSBs). Mono-allelic mutati...

RAD51C germline mutations found in Spanish site-specific breast cancer and br...

Blanco(Ana),Gutiérrez-Enríquez(Sara),Santa... Breast Cancer Res Treat 2015-09-21

BRCA1 and BRCA2 are the most well-known breast and ovarian cancer susceptibility genes. Additional genes involved in DNA...

Mammography screening and the risk of breast cancer in BRCA1 and BRCA2 mutati...

Giannakeas(Vasily),Lubinski(Jan),Gronwald(... Breast Cancer Res Treat 2015-09-21

...BRCA2 carriers. We identified 2,346 women with a BRCA1 (n = 1844) or BRCA2 (n = 502) mutation and no breast cancer, and ...

A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells.

Noble(Philip W),Young(Melissa R),Bernatsky... Sci Rep 2015-10-26

...BRCA2-proficient and deficient DLD1 colon cancer cells. 5C6 selectively induced γH2AX in, and suppressed the growth of, ...

PARP-inhibitors in BRCA-associated pancreatic cancer.

Bhalla(Anshul),Saif(Muhammad Wasif) JOP 2015-05-12

...BRCA2, and PALB2 with chemotherapy which targets the DNA repair defect in these cells, such as platinum based therapies ...

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