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Long-range PCR in next-generation sequencing: comparison of six enzymes and e...

Jia(Haiying),Guo(Yunfei),Zhao(Weiwei),Wang... Sci Rep 2015-11-02

...BRCA2 (84.2 kb) genes from nine subjects and sequenced them on an Illumina MiSeq sequencer. We found that the TaKaRa Pri...

Risk-reducing salpingo-oophorectomy: a meta-analysis on impact on ovarian can...

Marchetti(Claudia),De Felice(Francesca),Pa... BMC Womens Health 2015-07-23

...BRCA2 mutation carriers are at substantially elevated risk of developing ovarian cancer. The aim of the meta-analysis is...

Hereditary cancer-associated mutations in women diagnosed with two primary ca...

Saam(Jennifer),Moyes(Kelsey),Landon(Michel... Oncology 2015-06-11

...BRCA2 mutation. Among women with both colorectal and ovarian cancer, 28.1% (264/941) had a mutation associated with LS. ...

Beyond BRCA1 and BRCA2.

King-Spohn(Kimberly),Pilarski(Robert) Curr Probl Cancer 2015-07-22

...BRCA2-associated HBOC. Failure to identify a rare hereditary breast cancer syndrome can lead to additional cancer diagno...

Clinical management of women at high risk of breast cancer.

Wuttke(Melanie),Phillips(Kelly-Anne) Curr Opin Obstet Gynecol 2015-08-31

...BRCA2. Several observational studies have suggested that contralateral risk-reducing mastectomy, following a diagnosis o...

Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype.

Sawyer(Sarah L),Tian(Lei),Kähkönen(Markett... Cancer Discov 2015-10-22

...BRCA2 (FANCD1), PALB2 (FANCN), and BRIP1 (FANCJ), interact with BRCA1 during ICL repair. However, the lack of detailed p...

[The risk-reducing mastectomy: unnecessary hysteria or life-saving prophylaxi...

Olariu(Radu),Shafighi(Maziar),Constantines... Ther Umsch 2015-02-06

...BRCA2 mutation as well as other patient groups at increased breast cancer risk. This option should be offered to all pat...

Cycling with BRCA2 from DNA repair to mitosis.

Lee(Hyunsook) Exp Cell Res 2015-02-04

...BRCA2 in HDR and focus on the emerging roles of BRCA2 in telomere homeostasis and mitosis, then discuss how BRCA2 exerts...

Small-molecule inhibitors that target protein-protein interactions in the RAD...

Scott(Duncan E),Coyne(Anthony G),Venkitara... ChemMedChem 2015-09-29

...BRCA2 protein through a common "FxxA" tetrapeptide motif. We elaborated previously identified fragment hits that target ...

Incidence of BRCA1 and BRCA2 non-founder mutations in patients of Ashkenazi J...

Rosenthal(Eric),Moyes(Kelsey),Arnell(Chris... Breast Cancer Res Treat 2015-09-28

...BRCA2. Non-founder mutations make up between 7.2 and 13.0 % of all BRCA1 and BRCA2 mutations in Ashkenazi Jews. A wide r...

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