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BRCA1 haploinsufficiency leads to altered expression of genes involved in cel...

Feilotter(Harriet E),Michel(Claire),Uy(Pao... PLoS One 2015-02-12

...BRCA2 coding sequences to identify pathogenic mutations associated with inherited breast/ovarian cancer syndrome has pro...

Duration of tamoxifen use and the risk of contralateral breast cancer in BRCA...

Gronwald(Jacek),Robidoux(Andre),Kim-Sing(C... Breast Cancer Res Treat 2015-08-18

Women with a mutation in BRCA1 or BRCA2 face a lifetime risk of breast cancer of approximately 80 %. Tamoxifen treatment...

The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent...

Brohl(Andrew S),Solomon(David A),Chang(Wen... PLoS Genet 2015-02-12

...BRCA2 K3326X polymorphism in EFT patient samples (7.3%) compared to population data (OR 7.1, p = 0.006). Using whole tra...

A preliminary Quality Control (QC) for next generation sequencing (NGS) libra...

Concolino(Paola),Costella(Alessandra),Minu... Clin Chim Acta 2015-05-12

...BRCA2 gene) were identified.,We prove that a simple QC step may represent a valid and useful tool for a rapid detection ...

Association of BRCA2 variants with cardiovascular disease in Saudi Arabia.

Alanazi(M),Reddy(N P),Shaik(J P),Ajaj(S A)... Genet Mol Res 2015-02-12

Abnormalities in the breast cancer tumor suppressor genes (BRCA1 and BRCA2) are associated with breast and ovarian cance...

Molecular testing for the BRCA1 and BRCA2 Ashkenazi Jewish founder mutations:...

Tafe(Laura J),Datto(Michael B),Palomaki(Gl... Genet Med 2015-09-16

...BRCA2 genes.,Survey responses were analyzed for accuracy of genotype determination and the associated clinical interpret...

PARP inhibition and synthetic lethality in ovarian cancer.

Eskander(Ramez N),Tewari(Krishnansu S) Expert Rev Clin Pharmacol 2015-03-30

...BRCA2 gene mutations, and a more comprehensive assessment of heredity ovarian cancer syndrome, targeted interventions ex...

First evidence of a large CHEK2 duplication involved in cancer predisposition...

Tedaldi(Gianluca),Danesi(Rita),Zampiga(Val... BMC Cancer 2015-02-27

...BRCA2 and CHEK2 deletions and duplications. We identified a new 23-kb duplication in the CHEK2 gene extending from intro...

Expression status of let-7a and miR-335 among breast tumors in patients with ...

Erturk(Elif),Cecener(Gulsah),Egeli(Unal),T... Mol Cell Biochem 2015-10-29

...BRCA2. On the other hand, recent studies have indicated that alterations in the levels of miRNA expression are linked to...

BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell prolif...

Rytelewski(Mateusz),Tong(Jessica G),Buensu... Mol Oncol 2015-08-19

...BRCA2 is involved in homologous recombination repair. BRCA2 defects increase cancer risk but, paradoxically, cancer pati...

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