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Lack of association of BRCA1 and BRCA2 variants with breast cancer in an ethn...

Hasan(Tarique Noorul),Shafi(Gowhar),Syed(N... Asian Pac J Cancer Prev 2015-01-21

...BRCA2) and the risk of breast cancer. TaqMan based Real Time Polymerase chain reaction genotyping assays were used to de...

Development of primary early-onset colorectal cancers due to biallelic mutati...

Degrolard-Courcet(Emilie),Sokolowska(Joann... Eur J Hum Genet 2015-03-30

...BRCA2 with the point mutation c.7802A>G in the patients harbouring the biallelic FANCD1/BRCA2 mutations. Although this r...

High levels of BRC4 induced by a Tet-On 3G system suppress DNA repair and imp...

Abe(Takuya),Branzei(Dana) DNA Repair (Amst) 2015-06-24

...BRCA2 impairs cell proliferation and induces chromosomal breaks. Mechanistically, high levels of BRC4 suppress double st...

Clinicopathologic characteristics of breast cancer in BRCA-carriers and non-c...

Bayraktar(Soley),Amendola(Laura),Gutierrez... Breast 2015-08-24

...BRCA2-carriers were more likely to have a FH of male breast cancer compared to noncarriers (P = 0.02). Among BRCA2-carri...

BRCA1 germline mutations may be associated with reduced ovarian reserve.

Wang(Erica T),Pisarska(Margareta D),Bresee... Fertil Steril 2015-01-29

...BRCA2 carriers, and women without BRCA mutations (controls). None had a personal history of breast or ovarian cancer.,No...

Impact of a paternal origin of germline BRCA1/2 mutations on the age at breas...

Ellberg(Carolina),Jernström(Helena),Brober... Genes Chromosomes Cancer 2015-05-21

...BRCA2 mutations and time to breast or ovarian cancer diagnosis were found. An attempt to handle a potential selection bi...

Significant clinical impact of recurrent BRCA1 and BRCA2 mutations in Mexico.

Villarreal-Garza(Cynthia),Alvarez-Gómez(Ro... Cancer 2015-05-01

...BRCA2 among Hispanics, including a large rearrangement Mexican founder mutation (BRCA1 exon 9-12 deletion [ex9-12del]), ...

Transcriptional profiling and dynamical regulation analysis identify potentia...

Wang(Yang),Chen(Xiaomei),Chen(Xiaojing),Ch... Mol Cells 2015-06-30

...BRCA2 in HEK293T cells. Thus, we infer that SCYL1-BP1 plays a critical function in HEK293T cell development and directly...

Clinical and molecular characterization of the BRCA2 p.Asn3124Ile variant rev...

Surowy(Harald Martin),Sutter(Christian),Mi... Breast Cancer Res Treat 2015-11-12

...BRCA2 p.Asn3124Ile (BRCA2 c.9371A > T) variant is a rare mutation with a damaging effect on the BRCA2 protein that is st...

The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mi...

Song(Honglin),Cicek(Mine S),Dicks(Ed),Harr... Hum Mol Genet 2015-03-30

...BRCA2, with 84 EOC cases (3.8%) carrying a BRCA1 mutation and 94 EOC cases (4.2%) carrying a BRCA2 mutation. The combine...

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