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Use of risk-reducing surgeries in a prospective cohort of 1,499 BRCA1 and BRC...

Chai(Xinglei),Friebel(Tara M),Singer(Chris... Breast Cancer Res Treat 2015-07-14

...BRCA2 by age 40, and 86% for BRCA1 and 71% for BRCA2 by age 50. RRM usage was estimated to be 46% by age 70 in both BRCA...

Addressing sexual dysfunction after risk-reducing salpingo-oophorectomy: effe...

Bober(Sharon L),Recklitis(Christopher J),B... J Sex Med 2015-06-29

...BRCA2 mutation or family history are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) after age 35 or c...

Establishment and characterization of a receptor-negative, hormone-nonrespons...

Al-Shammari(Ahmed Majeed),Alshami(Mortadha... Breast Cancer (Dove Med Press) 2015-08-24

...BRCA2, as well as for vimentin. This cell line should be useful when testing new therapies for breast cancer in the Midd...

miRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) heredit...

Tanić(Miljana),Yanowski(Kira),Andrés(Eduar... Genom Data 2015-10-20

...BRCA2 gene, while mutations in other rare high and moderate-risk genes and common low penetrance variants may account fo...

Clinical Application of Multigene Panels: Challenges of Next-Generation Couns...

Slavin(Thomas Paul),Niell-Swiller(Mariana)... Front Oncol 2015-10-20

...BRCA2, MSH6, PMS2, TP53, APC, CDH1), the results would have been positive only 6.2% of the time, instead of 17%. Results...

The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach can...

Cavanagh(Helen),Rogers(Katherine M A) Hered Cancer Clin Pract 2015-08-03

...BRCA2) with the development of breast and ovarian cancers have been widely researched and recognised. It is known that t...

Much more than a gene: hereditary breast and ovarian cancer, reproductive cho...

Dekeuwer(Catherine),Bateman(Simone) Med Health Care Philos 2014-02-26

...BRCA2 gene, associated with a high risk of breast and ovarian cancer, make their reproductive decisions. Using semi-stru...

How do women at increased, but unexplained, familial risk of breast cancer pe...

Keogh(Louise A),McClaren(Belinda J),Apicel... Hered Cancer Clin Pract 2014-08-21

...BRCA2 mutation had been identified in their family. Data collection consisted of an audio recorded, semi-structured inte...

BRCA1 and BRCA2 mutations in breast cancer patients from Venezuela.

Lara(Karlena),Consigliere(Nigmet),Pérez(Jo... Biol Res 2014-01-07

...BRCA2 variants), 5 BRCA2 variants with no clinical importance and 22 polymorphisms (12 in BRCA1 and 10 in BRCA2) were al...

Germline BRCA1 and BRCA2 mutations in ovarian cancer: utility of a histology-...

Schrader(Kasmintan A),Hurlburt(Jane),Kallo... Obstet Gynecol 2014-06-27

To estimate the frequency of BRCA1 and BRCA2 germline mutations in women with nonmucinous epithelial ovarian carcinoma u...

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