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Olaparib shows promise in multiple tumor types.

Cancer Discov 2014-03-21

...BRCA2 gene mutations confirmed earlier results showing clinical benefit for advanced breast and ovarian cancers, and dem...

Diagnostic chest X-rays and breast cancer risk before age 50 years for BRCA1 ...

John(Esther M),McGuire(Valerie),Thomas(Dun... Cancer Epidemiol Biomarkers... 2014-06-11

...BRCA2 mutations.,We studied 454 BRCA1 and 273 BRCA2 mutation carriers ages younger than 50 years from three breast cance...

Genetic predisposition to radiation induced sarcoma: possible role for BRCA a...

Kadouri(Luna),Sagi(Michal),Goldberg(Yael),... Breast Cancer Res Treat 2014-02-10

...BRCA2 carriers. We report the genetic evaluation of seven cases with suspected RAS from patients counseled in our cancer...

A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolys...

Calderón-Montaño(José Manuel),Burgos-Morón... Planta Med 2014-07-01

...BRCA2 (deficient in homologous recombination repair) than in parental cells; this indicates that the induction of DNA da...

Low prevalence of germline PALB2 mutations in Australian triple-negative brea...

Wong-Brown(Michelle W),Avery-Kiejda(Kelly ... Int J Cancer 2014-04-15

...BRCA2; this raises the possibility that germline PALB2 mutations may be involved in the pathogenesis of TNBCs. In our st...

Functional analysis of BRCA1 missense variants of uncertain significance in J...

Kawaku(Shogo),Sato(Rieko),Song(Hao),Bando(... J Hum Genet 2014-04-02

...BRCA2 are responsible for a large proportion of familial breast cancer cases, and therefore, BRCA1 and BRCA2 genetic tes...

Clinical-pathologic significance of cancer stem cell marker expression in fam...

Bane(Anita),Viloria-Petit(Alicia),Pinnaduw... Breast Cancer Res Treat 2014-02-10

...BRCA2-associated, and 242 familial non-BRCA1/2 cancers) were studied. Each tumor had a centralized pathology review perf...

Identification of a novel BRCA2 and CHEK2 A-C-G-C haplotype in Turkish patien...

Haytural(Hazal),Yalcinkaya(Nazli),Akan(Gok... Asian Pac J Cancer Prev 2014-10-14

...BRCA2 and CHEK2. The aim of this study was to examine the allele and genotype frequencies of seven mutations in BRCA1, B...

Health care provider recommendations for reducing cancer risks among women wi...

Metcalfe(K A),Kim-Sing(C),Ghadirian(P),Sun... Clin Genet 2014-07-18

There is a significant variation in the uptake of cancer risk reducing options by women with a BRCA1 or BRCA2 mutation. ...

Tumour diploidy and survival in breast cancer patients with BRCA2 mutations.

Tryggvadottir(Laufey),Olafsdottir(Elinborg... Breast Cancer Res Treat 2014-03-17

...BRCA2 mutation affects the survival of women with breast cancer and prognostic factors among BRCA2-positive women warran...

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