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Tumour diploidy and survival in breast cancer patients with BRCA2 mutations.

Tryggvadottir(Laufey),Olafsdottir(Elinborg... Breast Cancer Res Treat 2014-03-17

...BRCA2 mutation affects the survival of women with breast cancer and prognostic factors among BRCA2-positive women warran...

Constitutional CHEK2 mutations are infrequent in early-onset and familial bre...

Rashid(Muhammad U),Muhammad(Noor),Faisal(S... BMC Cancer 2014-01-10

...BRCA2 and TP53. Thus, mutations in other genes confer genetic susceptibility to breast cancer, of which CHEK2 is a plaus...

Identification of a novel BRCA2 and CHEK2 A-C-G-C haplotype in Turkish patien...

Haytural(Hazal),Yalcinkaya(Nazli),Akan(Gok... Asian Pac J Cancer Prev 2014-10-14

...BRCA2 and CHEK2. The aim of this study was to examine the allele and genotype frequencies of seven mutations in BRCA1, B...

ATM release at resected double-strand breaks provides heterochromatin reconst...

Geuting(Verena),Reul(Christian),Löbrich(Ma... PLoS Genet 2014-03-21

...BRCA2, XRCC3 or RAD51. Strikingly, depletion of KAP-1 or expression of phospho-mimic KAP-1 allows repair of resected DSB...

Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovar...

Blanco(Ana),de la Hoya(Miguel),Osorio(Ana)... PLoS One 2014-03-05

The PALB2 gene, also known as FANCN, forms a bond and co-localizes with BRCA2 in DNA repair. Germline mutations in PALB2...

Analysis of several BRCA1 and BRCA2 mutations in a hospital-based series of u...

Burcoş(T),Cimponeriu(D),Ion(D A),Spandole(... Chirurgia (Bucur) 2014-01-15

The distribution of BRCA mutations varies significantly between populations. The spectrum of BRCA1 and BRCA2 mutations i...

Identifying Lynch syndrome in patients with ovarian carcinoma: the significan...

Chui(Michael Herman),Gilks(C Blake),Cooper... Adv Anat Pathol 2014-05-12

...BRCA2. Clinical schemas specific for gynecologic cancers have been developed to identify patients with LS; however, many...

Multidisciplinary one-stage risk-reducing gynaecological and breast surgery w...

Khadim(M F),Eastwood(P),Price(J),Morrison(... Eur J Surg Oncol 2014-01-31

...BRCA2 and a quarter were BRCA1 carriers. The rest were positive for both genes. Hormone-replacement therapy was initiate...

Disclosure pattern and follow-up after the molecular diagnosis of BRCA/CHEK2 ...

Kegelaers(D),Merckx(W),Odeurs(P),van den E... J Genet Couns 2014-11-14

...BRCA2. In families with known BRCA mutations, disclosure of genetic test results could induce relatives to undergo genet...

The psychological impact of breast and ovarian cancer preventive options in B...

Borreani(C),Manoukian(S),Bianchi(E),Brunel... Clin Genet 2014-07-18

This study was performed to describe the impact of preventive options on the psychological condition of BRCA1/BRCA2 carr...

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