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The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies.

Reinbolt(Raquel E),Hays(John L) Front Oncol 2014-06-24

...BRCA2 genes. However, pre-clinical research and clinical trials have suggested that the activity of PARP inhibitors is n...

Formaldehyde induces toxic effects and regulates the expression of damage res...

She(Yali),Li(Yi),Liu(Yongqi),Asai(Guli),Su... Acta Biochim Biophys Sin (S... 2014-07-25

...Brca2, Rad51, and Xrcc2 of the homologous recombination pathway were all up-regulated in both 75 and 125 μM FA. However,...

Differential BCCIP gene expression in primary human ovarian cancer, renal cel...

Liu(Xiaoxia),Cao(Lingling),Ni(Jinsong),Liu... Int J Oncol 2014-07-14

Human BCCIP, a protein which interacts with BRCA2 and CDKN1A (Cip1, p21), has been implicated in many cellular processes...

A clinically validated diagnostic second-generation sequencing assay for dete...

Bosdet(Ian E),Docking(T Roderick),Butterfi... J Mol Diagn 2014-06-05

Individuals who inherit mutations in BRCA1 or BRCA2 are predisposed to breast and ovarian cancers. However, identifying ...

Carcinogenesis of pancreatic adenocarcinoma: precursor lesions.

Gnoni(Antonio),Licchetta(Antonella),Scarpa... Int J Mol Sci 2014-04-24

...BRCA2 genes. However, other molecular events involved in pancreatic adenocarcinoma pathogenesis contribute to its develo...

An investigation of the effects of FGFR2 and B7-H4 polymorphisms in breast ca...

Ozgöz(Asuman),Samli(Hale),Oztürk(Kuyaș Hek... J Cancer Res Ther 2014-08-07

...BRCA2, PTEN, and TP53, can be investigated as potential modifiers of high penetrant risk alleles. Although the B7-H4 gen...

Appraising iniparib, the PARP inhibitor that never was--what must we learn?

Mateo(Joaquin),Ong(Michael),Tan(David S P)... Nat Rev Clin Oncol 2014-07-24

...BRCA2, with further data supporting antitumour activity of PARP inhibitors in sporadic ovarian cancer. Strategies to ide...

MicroRNA signatures in hereditary breast cancer.

Murria Estal(Rosa),Palanca Suela(Sarai),de... Breast Cancer Res Treat 2014-06-09

...BRCA2 and RASSF1 methylation analysis, AURKA copy number variations, and BRCA1 and BRCA2 deletions, were studied by MLPA...

About 1% of the breast and ovarian Spanish families testing negative for BRCA...

Gutiérrez-Enríquez(Sara),Bonache(Sandra),d... Int J Cancer 2014-04-02

...BRCA2 mutations. We analyzed 842 index patients: 491 from BC/OC families, 171 BC families, 51 OC families and 129 patien...

Experience of BRCA1/2 mutation-negative young women from families with heredi...

Macrae(Lynn),de Souza(Alicia Navarro),Lois... Hered Cancer Clin Pract 2014-01-17

...BRCA2 (BRCA) mutation status as adolescents or young adults. There is also currently a gap in the literature pertaining ...

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