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Arsenic exposure alters expression of cell cycle and lipid metabolism genes i...

Carlson(Patrick),Van Beneden(Rebecca J) Aquat Toxicol 2014-08-01

...brca2)] and lipid transport and metabolism [carnitine O-octanoyltransferase (crot), fatty acid binding protein-3 (fabp3)...

Differences in DNA methylation by extent of breast cancer family history in u...

Delgado-Cruzata(Lissette),Wu(Hui-Chen),Lia... Epigenetics 2014-10-28

...BRCA2 mutation carriers. We used generalized estimated equation models to test for differences in DNA methylation levels...

Nibrin is a marker of clinical outcome in patients with advanced serous ovari...

Monk(Bradley J),Kaye(Stanley B),Poveda(And... Gynecol Oncol 2014-04-24

...BRCA2 levels (P=0.03) and a worse PFS, and between high nibrin levels and a worse OS (P=0.006).,Our results indicate tha...

Comparison of mRNA splicing assay protocols across multiple laboratories: rec...

Whiley(Phillip J),de la Hoya(Miguel),Thoma... Clin Chem 2014-03-17

...BRCA2) gene variants known to alter splicing (BRCA1: c.135-1G>T, c.591C>T, c.594-2A>C, c.671-2A>G, and c.5467+5G>C and B...

Endogenous levels of Rad51 and Brca2 are required for homologous recombinatio...

Magwood(Alissa C),Malysewich(Michael J),Ce... DNA Repair (Amst) 2014-07-15

...Brca2) protein. Additionally, hybridoma cell lines that are siRNA depleted for mouse Brca2 show a corresponding reductio...

Family history and BRCA1/BRCA2 status among Japanese ovarian cancer patients ...

Hirasawa(Akira),Masuda(Kenta),Akahane(Tomo... Jpn J Clin Oncol 2014-03-03

...BRCA2 mutations. One case underwent risk-reductive salpingo-oophorectomy as a BRCA1 mutant carrier was retrospectively d...

Hypersensitivities for acetaldehyde and other agents among cancer cells null ...

Ghosh(Soma),Sur(Surojit),Yerram(Sashidhar ... Am J Pathol 2014-08-18

...BRCA2/FANCD1-null, and PALB2/FANCN-null phenotypes was confirmed by uniform tumor regression on single-dose cross-linker...

Mechanisms of resistance to therapies targeting BRCA-mutant cancers.

Lord(Christopher J),Ashworth(Alan) Nat Med 2014-01-23

...BRCA2 tumor suppressor proteins, which are involved in the repair of DNA damage. Although this approach has shown promis...

A clinical trial of lovastatin for modification of biomarkers associated with...

Vinayak(Shaveta),Schwartz(Erich J),Jensen(... Breast Cancer Res Treat 2014-08-14

...BRCA2, CDH1, or TP53; lifetime breast cancer risk of ≥20 % as estimated by the Claus model; or personal history of estro...

Hypoxia and human genome stability: downregulation of BRCA2 expression in bre...

Fanale(Daniele),Bazan(Viviana),Caruso(Stef... Biomed Res Int 2014-06-12

...BRCA2 in hypoxic conditions in breast cancer. Initially, a cell proliferation assay allowed us to hypothesize that hypox...

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