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Malacaria(E),Figlioli(C),Palma(A),Honda(M)... Nucleic Acids Res 2026-08-10

...BRCA2-deficient cells. However, how MUS81 is regulated during replication stress in human cells remains unknown. Our stu...

Nugrohowati(N),Ratri(LA),Kusuma(T),Widodo(... Iran J Pathol 2026-09-01

...BRCA2 immunohistochemistry was negative. The metachronous occurrence of triple-negative invasive ductal carcinoma and pr...

Xu(Y),Lei(Q),Yang(S),Zhang(Y),Luo(X),Song(... Eur J Med Chem 2026-08-16

...BRCA2 and RAD51, thereby triggering enhanced DNA damage and cell apoptosis. Notably, in the BRCA wild-type MDA-MB-231 xe...

Incorvaia(L),Santini(D),Matrana(MR),Maruzz... Int J Cancer 2026-08-18

...BRCA2 was 23% versus 39%, respectively (p = 0.021). Frameshift PVs in the BRCA2 gene were a prognostic factor for shorte...

Dossa(F),Metcalfe(K),Ante(Z),Liu(N),Lerner... JAMA Netw Open 2026-07-01

Pathogenic variants in BRCA1 and BRCA2 confer substantial risks of breast and ovarian cancer; however, risk for female i...

Harano(K),Nakao(T),Nishio(S),Katsuda(T),Ta... Clin Cancer Res 2026-07-30

...BRCA2-mutated tumors (5/5, 100%). In Cohort 2, ORR was 84.6% (11/13) in BRCA1/2-mutated tumors and 42.9% (3/7) in non-BR...

Irmejs(A),Daneberga(Z),Kiploka(K),Augucevi... Eur J Hum Genet 2026-07-30

Pathogenic variants in BRCA1 and BRCA2 account for the majority of hereditary breast and ovarian cancer (HBOC) cases, an...

Broad(SR),Wei(J),Denson(K),Shi(Z),Naeem(W)... Ann Thorac Surg 2026-07-31

...BRCA2, TP53) and five novel genes (RB1, MET, CYLD, PDGFRA, CTNNA1). In the UK Biobank incident lung cancer cohort, aggre...

Zou(Z),Lu(G),Xin(M),Du(Z),Cheng(Z),Wu(S),C... J Med Chem 2026-08-13

...BRCA2-deficient cell line (Capan-1). Mechanistic studies revealed that 24c effectively inhibited intracellular PARP-1 ac...

Chen(MY),Zhou(JL),Zhang(XY),Zhai(QZ),Li(MX... Zhonghua Zhong Liu Za Zhi 2026-07-23

...BRCA2 mutation group (29 cases). The clinical baseline data, pathological characteristics, treatment efficacy, and survi...