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SoftSearch: integration of multiple sequence features to identify breakpoints...

Hart(Steven N),Sarangi(Vivekananda),Moore(... PLoS One 2014-10-21

...BRCA2 gene not reported by other tools while offering significantly improved overall performance.

BRCA2: one small step for DNA repair, one giant protein purified.

Jensen(Ryan B) Yale J Biol Med 2014-08-13

...BRCA2. The role of BRCA2 in DNA double-strand break repair was first revealed based on its interaction with RAD51, a cen...

Reproductive factors and breast cancer risk among BRCA1 or BRCA2 mutation car...

Pan(Hong),He(Zhongyuan),Ling(Lijun),Ding(Q... Cancer Epidemiol 2014-11-02

...BRCA2 mutation carriers. This meta-analysis is the first to be performed to determine the relationship between reproduct...

Mutational analysis of the BRCA2 gene in breast carcinoma patients of Kashmir...

Ayub(Shiekh Gazalla),Rasool(Shabhat),Ayub(... Mol Med Rep 2014-08-26

...BRCA2 gene in a case control manner in ethnically pure Kashmiri population using PCR. Sequencing of BRCA2 exons revealed...

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a no...

Bajrami(Ilirjana),Frankum(Jessica R),Konde... Cancer Res 2014-05-27

...BRCA2 mutations. Indeed, in clinical trials, PARP1/2 inhibitors elicit sustained antitumor responses in patients with ge...

Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffec...

Ingham(Sarah L),Sperrin(Matthew),Baildam(A... Breast Cancer Res Treat 2014-07-18

...BRCA2. 105 BRCA1 carriers and 122 BRCA2 carriers developed breast cancer during follow-up. The hazard of death was stati...

Familial pancreatic cancer: genetic advances.

Rustgi(Anil K) Genes Dev 2014-02-20

...BRCA2 mutations (usually in association with hereditary breast-ovarian cancer syndrome), CDKN2 mutations (familial atypi...

The clinical utility of biomarkers in the management of pancreatic adenocarci...

Jazieh(Khalid A),Foote(Michael B),Diaz(Lui... Semin Radiat Oncol 2014-11-24

...BRCA2, PALB2, and SPARC so as to determine their influence on tumor response on targeted therapies. As research progress...

Mitochondrial DNA variants and risk of familial breast cancer: an exploratory...

Tommasi(Stefania),Favia(Paola),Weigl(Stefa... Int J Oncol 2014-11-13

...BRCA2 mutations, 14 sporadic BC patients and 20 healthy subjects were analyzed. In the D-loop and in the MTND4 region, v...

Identification of cellular and genetic drivers of breast cancer heterogeneity...

Melchor(Lorenzo),Molyneux(Gemma),Mackay(Al... J Pathol 2014-07-10

...Brca2, Pten and p53 were depleted in either basal mammary epithelial cells or luminal oestrogen receptor (ER)-negative c...

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